Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042794 | 0.89 | KDM4E (0.50) | P2RX7ALDH1A1HTTKDM4ERECQL | |
| SCHEMBL20042705 | 0.86 | EPHX2 (0.45) | P2RX7LMNATP53 | |
| SCHEMBL20042917 | 0.85 | P2RX7 (0.39) | P2RX7HTTLMNAKDM4E | |
| SCHEMBL20042685 | 0.85 | HTT (0.42) | P2RX7HTTSMN1; SMN2GBA1KCNH2 | |
| SCHEMBL20042653 | 0.85 | P2RX7 (0.37) | P2RX7LMNATSHRNR4A1SMN1; SMN2 | |
| SCHEMBL20042817 | 0.85 | PKM (0.44) | P2RX7ALDH1A1LMNAGBA1KDM4E | |
| SCHEMBL20042911 | 0.85 | P2RX7 (0.39) | P2RX7ALDH1A1HTTLMNAKDM4E | |
| SCHEMBL20042751 | 0.83 | HSD17B10 (0.49) | P2RX7ALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL20042839 | 0.82 | P2RX7 (0.45) | P2RX7ALDH1A1HTTTSHRSMN1; SMN2 | |
| SCHEMBL20042704 | 0.82 | P2RX7 (0.50) | P2RX7ALDH1A1HTTTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |