Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042668 | 0.89 | HPGD (0.51) | SMN1; SMN2P2RX7LMNAALDH1A1HPGD | |
| SCHEMBL20042829 | 0.89 | P2RX7 (0.41) | SMN1; SMN2P2RX7HPGDKDM4EGRM5 | |
| SCHEMBL20042771 | 0.87 | P2RX7 (0.47) | SMN1; SMN2P2RX7LMNAALDH1A1HPGD | |
| SCHEMBL20042685 | 0.87 | HTT (0.42) | SMN1; SMN2P2RX7ABL1BCRCYP1A2 | |
| SCHEMBL20042652 | 0.87 | P2RX7 (0.66) | SMN1; SMN2P2RX7LMNAALDH1A1HPGD | |
| SCHEMBL20042839 | 0.87 | P2RX7 (0.45) | SMN1; SMN2P2RX7ALDH1A1HPGDKDM4E | |
| SCHEMBL20042666 | 0.86 | KMT2A (0.46) | P2RX7GRM5KCNH2 | |
| SCHEMBL20042823 | 0.85 | P2RX7 (0.45) | P2RX7LMNAALDH1A1HPGDTSHR | |
| SCHEMBL20042836 | 0.85 | P2RX7 (0.43) | SMN1; SMN2P2RX7ALDH1A1HPGDTDP1 | |
| SCHEMBL20042794 | 0.85 | KDM4E (0.50) | P2RX7ALDH1A1HPGDKDM4EGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |