Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042684 | 0.89 | SMN1; SMN2 (0.52) | HPGDP2RX7GRM5KDM4EHTT | |
| SCHEMBL20042771 | 0.89 | P2RX7 (0.47) | HPGDP2RX7GRM5KDM4EHTT | |
| SCHEMBL20042839 | 0.89 | P2RX7 (0.45) | HPGDP2RX7GBA1KDM4EHTT | |
| SCHEMBL20042721 | 0.86 | GRM5 (0.47) | P2RX7GRM5L3MBTL1MEN1KMT2A | |
| SCHEMBL20042652 | 0.86 | P2RX7 (0.66) | HPGDP2RX7GRM5KDM4EHTT | |
| SCHEMBL20042817 | 0.86 | PKM (0.44) | HPGDP2RX7GBA1KDM4ELMNA | |
| SCHEMBL20042671 | 0.85 | P2RX7 (0.45) | HPGDP2RX7GBA1HTTALDH1A1 | |
| SCHEMBL20042794 | 0.85 | KDM4E (0.50) | HPGDP2RX7GRM5KDM4EHTT | |
| SCHEMBL20042872 | 0.84 | P2RX7 (0.44) | P2RX7GBA1LMNASMN1; SMN2 | |
| SCHEMBL20042873 | 0.84 | P2RX7 (0.38) | HPGDP2RX7GBA1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |