Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042704 | 0.88 | P2RX7 (0.50) | P2RX7HPGDALDH1A1ABL1BCR | |
| SCHEMBL20043089 | 0.87 | P2RX7 (0.52) | P2RX7LMNAABL1BCRSMN1; SMN2 | |
| SCHEMBL20042684 | 0.87 | SMN1; SMN2 (0.52) | P2RX7LMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL20042668 | 0.86 | HPGD (0.51) | P2RX7LMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL20042702 | 0.85 | P2RX7 (0.49) | P2RX7SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL20042771 | 0.85 | P2RX7 (0.47) | P2RX7LMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL20042839 | 0.84 | P2RX7 (0.45) | P2RX7HPGDKDM4EALDH1A1NPSR1 | |
| SCHEMBL20042794 | 0.82 | KDM4E (0.50) | P2RX7POLBHPGDKDM4EALDH1A1 | |
| SCHEMBL20042760 | 0.82 | P2RX7 (0.45) | P2RX7ABL1BCRMEN1KMT2A | |
| SCHEMBL20042721 | 0.82 | GRM5 (0.47) | P2RX7GRM5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |