Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 8/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20042857 | 0.88 | PROKR1 (0.35) | PROKR1RAB9ACYP11B1KDM4EALDH1A1 | |
| SCHEMBL20042742 | 0.80 | PROKR1 (0.35) | PROKR1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL20042844 | 0.79 | P2RX7 (0.33) | KMT2AKDM4EPIK3CDSMN1; SMN2MAPT | |
| SCHEMBL20042865 | 0.79 | TACR3 (0.42) | CYP2C19 | |
| SCHEMBL20042958 | 0.79 | TACR3 (0.42) | CYP2C19 | |
| SCHEMBL20042982 | 0.79 | P2RX7 (0.46) | KMT2AALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL20042851 | 0.79 | P2RX7 (0.46) | KMT2AALDH1A1POLBGAASMN1; SMN2 | |
| SCHEMBL20042767 | 0.78 | TACR3 (0.44) | ALDH1A1 | |
| SCHEMBL20042896 | 0.77 | GRM5 (0.38) | LMNA | |
| SCHEMBL20042766 | 0.77 | TACR3 (0.36) | KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018066718-A1 | THERAPEUTIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-04-12 | — | — | WO | disclosed |