Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | EDNRB | P24530 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007918 | 0.93 | ALOX5AP (0.40) | S1PR1ALOX5APLMNASMN1; SMN2MAPT | |
| SCHEMBL2005736 | 0.92 | DGAT2 (0.39) | LMNASMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL2003734 | 0.91 | ALOX5AP (0.42) | S1PR1ALOX5APLMNASMN1; SMN2MAPT | |
| SCHEMBL2004267 | 0.91 | S1PR1 (0.42) | S1PR1ALOX5APLMNASMN1; SMN2MAPT | |
| SCHEMBL2003150 | 0.90 | S1PR1 (0.35) | S1PR1ALOX5APLMNASMN1; SMN2MAPT | |
| SCHEMBL1999738 | 0.90 | CYP2C9 (0.39) | LMNASMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL2002148 | 0.90 | LMNA (0.34) | ALOX5APLMNASMN1; SMN2MAPTF10 | |
| SCHEMBL2004301 | 0.88 | RAB9A (0.36) | LMNASMN1; SMN2MAPTALDH1A1CYP3A4 | |
| SCHEMBL2006974 | 0.88 | LMNA (0.38) | S1PR1ALOX5APLMNASMN1; SMN2MAPT | |
| SCHEMBL2005759 | 0.87 | L3MBTL1 (0.39) | LMNASMN1; SMN2MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |