Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10641518 | 0.85 | ALDH1A1 (0.57) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL31535977 | 0.83 | TRPV4 (0.56) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL10638959 | 0.81 | ALDH1A1 (0.46) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL13100208 | 0.77 | TRPV4 (0.51) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL739940 | 0.75 | KMT2A (0.60) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL750886 | 0.75 | TRPV4 (0.73) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL407215 | 0.75 | L3MBTL1 (0.64) | TRPV4ALDH1A1SMN1; SMN2NPSR1CA1 | |
| SCHEMBL5012595 | 0.75 | SMN1; SMN2 (0.59) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL38243330 | 0.75 | TRPV4 (0.73) | TRPV4ALDH1A1SMN1; SMN2POLBTSHR | |
| SCHEMBL29482636 | 0.75 | L3MBTL1 (0.64) | TRPV4ALDH1A1SMN1; SMN2NPSR1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3309146-A1 | SULFONAMIDE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF | University of Tsukuba (JP) | 2018-04-18 | — | — | EP | disclosed |