Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004791 | 0.93 | MAPT (0.44) | MAPTMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL2002616 | 0.93 | ALDH1A1 (0.45) | MAPTMEN1KMT2ACYP3A4TP53 | |
| SCHEMBL2003126 | 0.92 | MEN1 (0.44) | MEN1KMT2APPARGHSD17B10PTGES2 | |
| SCHEMBL1999686 | 0.91 | MAPT (0.42) | MAPTMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL2006285 | 0.91 | HSD17B10 (0.39) | MAPTMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL2004973 | 0.90 | PTGES2 (0.42) | MAPTMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL1999556 | 0.90 | PLA2G2A (0.49) | MAPTMEN1KMT2ACYP3A4TSHR | |
| SCHEMBL2004203 | 0.89 | ALOX5AP (0.45) | CYP3A4RECQLHSD17B10ALDH1A1KDM4E | |
| SCHEMBL2003741 | 0.88 | MAPT (0.41) | MAPTMEN1KMT2ACYP3A4ALOX15 | |
| SCHEMBL2007882 | 0.87 | HSD17B10 (0.40) | MAPTMEN1KMT2ACYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |