Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19703814 | 0.92 | HDAC3 (0.44) | LMNAHSD17B10HDAC3HDAC4HDAC1 | |
| SCHEMBL21236714 | 0.88 | LMNA (0.39) | LMNAHSD17B10HDAC3HDAC4HDAC1 | |
| SCHEMBL10017830 | 0.86 | KMT2A (0.36) | LMNAHSD17B10HDAC3HDAC4HDAC1 | |
| SCHEMBL17944136 | 0.85 | SIGMAR1 (0.38) | HSD17B10HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22203083 | 0.85 | HDAC3 (0.38) | LMNAHSD17B10HDAC3HDAC4HDAC1 | |
| SCHEMBL21933100 | 0.84 | TP53 (0.39) | HSD17B10HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20647310 | 0.84 | SMN1; SMN2 (0.41) | LMNAHSD17B10HDAC3HDAC4HDAC1 | |
| SCHEMBL18557296 | 0.84 | LMNA (0.44) | LMNAHSD17B10HDAC3HDAC4HDAC1 | |
| SCHEMBL21928974 | 0.83 | ALDH1A1 (0.34) | HSD17B10HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17944164 | 0.83 | HDAC3 (0.37) | HSD17B10HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10350290-B2 | Linear chimeric compounds and methods of use thereof | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2019-07-16 | — | — | US | disclosed |
| US-9950064-B2 | Branched and linear chimeric compounds, polynucleotides, uses and methods for preparation thereof | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2018-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10350290-B2 | Linear chimeric compounds and methods of use thereof | PAICS, HAVCR2, DCLRE1B | LMNA 1441/4885HSD17B10 4016/4885HDAC3 4697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.