Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 6/20 | 0.33 |
| ▸ | NOS2 | P35228 | 6/20 | 0.33 |
| ▸ | NOS3 | P29474 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.32 |
| ▸ | LOX | P28300 | 2/20 | 0.32 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11580037 | 0.84 | KMT2A (0.37) | MEN1KMT2ANOS1NOS2NOS3 | |
| SCHEMBL11581329 | 0.81 | MEN1 (0.38) | MEN1KMT2A | |
| SCHEMBL8390740 | 0.81 | CA2 (0.40) | MEN1KMT2AALDH1A1CYP3A4NFKB1 | |
| SCHEMBL29836971 | 0.79 | SKP2 (0.46) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL665154 | 0.77 | MEN1 (0.39) | MEN1KMT2AALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL8390737 | 0.76 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL9615157 | 0.76 | SKP2 (0.41) | ALDH1A1CYP3A4 | |
| SCHEMBL38660687 | 0.76 | TDP1 (0.41) | MEN1KMT2ANOS1NOS2NOS3 | |
| SCHEMBL317019 | 0.73 | MEN1 (0.39) | MEN1KMT2ANOS1NOS2NOS3 | |
| SCHEMBL31142510 | 0.73 | MEN1 (0.39) | MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110294118-A1 | WATER SOLUBLE FLUORESCENT COMPOUNDS | BIOSEARCH TECHNOLOGIES, INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110294118-A1 | WATER SOLUBLE FLUORESCENT COMPOUNDS | BIOSEARCH TECHNOLOGIES, INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-7964361-B2 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY (US) | 2011-06-21 | — | — | US | disclosed |
| US-7868157-B2 | low non-specific binding, photostable, ease of chemical modification to permit tuning of absorption and emission wavelengths and resistance to the formation of dimers; 1-(5-carboxy-pentyl)-2-[5-(1-ethyl-3,3-dimethyl-5-phosphono-1,3-dihydro-indol-2-ylidene)-penta-1,3-dienyl]-3,3-dimethyl-3H-indolium | BIOSEARCH TECHNOLOGIES, INC. (US) | 2011-01-11 | — | — | US | disclosed |
| US-7868157-B2 | low non-specific binding, photostable, ease of chemical modification to permit tuning of absorption and emission wavelengths and resistance to the formation of dimers; 1-(5-carboxy-pentyl)-2-[5-(1-ethyl-3,3-dimethyl-5-phosphono-1,3-dihydro-indol-2-ylidene)-penta-1,3-dienyl]-3,3-dimethyl-3H-indolium | BIOSEARCH TECHNOLOGIES, INC. (US) | 2011-01-11 | — | — | US | disclosed |
| US-7868157-B2 | low non-specific binding, photostable, ease of chemical modification to permit tuning of absorption and emission wavelengths and resistance to the formation of dimers; 1-(5-carboxy-pentyl)-2-[5-(1-ethyl-3,3-dimethyl-5-phosphono-1,3-dihydro-indol-2-ylidene)-penta-1,3-dienyl]-3,3-dimethyl-3H-indolium | BIOSEARCH TECHNOLOGIES, INC. (US) | 2011-01-11 | — | — | US | disclosed |
| US-20090281279-A1 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY (US) | 2009-11-12 | — | — | US | disclosed |
| US-7408062-B2 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY (US) | 2008-08-05 | — | — | US | disclosed |
| US-20070243527-A9 | RIGIDIZED TRIMETHINE CYANINE DYES | CARNEGIE MELLON UNIVERSITY | 2007-10-18 | — | — | US | disclosed |
| US-20070021621-A1 | Water soluble fluorescent compounds | BIOSEARCH TECHNOLOGIES, INC. (US) | 2007-01-25 | — | — | US | disclosed |
| US-20070021621-A1 | Water soluble fluorescent compounds | BIOSEARCH TECHNOLOGIES, INC. (US) | 2007-01-25 | — | — | US | disclosed |
| US-20070021621-A1 | Water soluble fluorescent compounds | BIOSEARCH TECHNOLOGIES, INC. (US) | 2007-01-25 | — | — | US | disclosed |
| US-6686145-B1 | IMPARTING FLUORESCENT PROPERTIES TO TARGET MATERIALS BY COVALENT AND NONCOVALENT ASSOCIATION | CARNEGIE MELLON UNIVERSITY | 2004-02-03 | — | — | US | disclosed |
| US-20030224391-A1 | Rigidized trimethine cyanine dyes | CARNEGIE MELLON UNIVERSITY | 2003-12-04 | — | — | US | disclosed |
| EP-1042407-B1 | RIGIDIZED TRIMETHINE CYANINE DYES | UNIV CARNEGIE MELLON (US) | 2001-09-12 | — | — | EP | disclosed |
| US-6133445-A | USEFUL FOR IMPARTING FLUORESCENT PROPERTIES TO TARGET MATERIALS | CARNEGIE MELLON UNIVERSITY (US) | 2000-10-17 | — | — | US | disclosed |
| EP-1042407-A1 | RIGIDIZED TRIMETHINE CYANINE DYES | CARNEGIE-MELLON UNIVERSITY (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031181-A1 | RIGIDIZED TRIMETHINE CYANINE DYES | CARNEGIE MELLON UNIVERSITY (US) | 1999-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070243527-A9 | RIGIDIZED TRIMETHINE CYANINE DYES | SIGMAR1, CBR1, NR0B1 | MEN1 3950/4885KMT2A 971/4885NOS1 383/4885 |
| US-20110294118-A1 | WATER SOLUBLE FLUORESCENT COMPOUNDS | ABCG2, AQP1, AQP3 | MEN1 2465/4885KMT2A 3963/4885NOS1 1062/4885 |
| US-20090281279-A1 | Rigidized trimethine cyanine dyes | CD47, TLN1, TPM4 | MEN1 3776/4885KMT2A 859/4885NOS1 840/4885 |
| US-20030224391-A1 | Rigidized trimethine cyanine dyes | CBR1, TH, CBR3 | MEN1 4371/4885KMT2A 769/4885NOS1 88/4885 |
| US-20070021621-A1 | Water soluble fluorescent compounds | ABCG2, AQP1, AQP3 | MEN1 2465/4885KMT2A 3963/4885NOS1 1062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.