Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751418 | 0.83 | POLB (0.43) | POLBSOAT1ALDH1A1TRPA1LMNA | |
| SCHEMBL9662247 | 0.82 | ALDH1A1 (0.40) | POLBSOAT1ALDH1A1TRPA1LMNA | |
| SCHEMBL11581057 | 0.80 | ALOX15 (0.48) | POLBSOAT1ALDH1A1TRPA1LMNA | |
| SCHEMBL5115722 | 0.76 | POLB (0.44) | POLBSOAT1ALDH1A1TRPA1LMNA | |
| SCHEMBL4671349 | 0.74 | POLB (0.43) | POLBSOAT1ALDH1A1TRPA1LMNA | |
| SCHEMBL10723830 | 0.74 | POLB (0.43) | POLBSOAT1ALDH1A1TRPA1LMNA | |
| SCHEMBL12764947 | 0.73 | POLB (0.40) | POLBSOAT1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL23177042 | 0.72 | POLB (0.42) | POLBSOAT1ALDH1A1TRPA1LMNA | |
| SCHEMBL11019559 | 0.72 | LMNA (0.51) | POLBALDH1A1LMNAGAAMEN1 | |
| SCHEMBL1968188 | 0.72 | POLB (0.46) | POLBSOAT1ALDH1A1TRPA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3165522-B1 | CYCLOPROPYL UNSATURATED QUINOLINE COMPOUND AS LEUKOTRIENE RECEPTOR ANTAGONIST AND USE THEREOF IN THERAPY | GUANGDONG MOLTECH PHARMA CO LTD (CN) | 2019-08-21 | — | — | EP | disclosed |
| US-20190248746-A1 | CYCLOPROPYL UNSATURATED QUINOLINE COMPOUND USED AS LEUKOTRIENE RECEPTOR ANTAGONIST AND APPLICATIONS THEREOF | GUANGDONG MOLTECH PHARMA CO LTD (CN) | 2019-08-15 | — | — | US | disclosed |
| US-10315997-B2 | Cyclopropyl unsaturated quinoline compound used as leukotriene receptor antagonist and applications thereof | GUANGDONG MOLTECH PHARMA CO., LTD. (CN) | 2019-06-11 | — | — | US | disclosed |
| US-20180118687-A1 | CYCLOPROPYL UNSATURATED QUINOLINE COMPOUND USED AS LEUKOTRIENE RECEPTOR ANTAGONIST AND APPLICATIONS THEREOF | GUANGDONG MOLTECH PHARMA CO., LTD. (CN) | 2018-05-03 | — | — | US | disclosed |
| US-20180118687-A1 | CYCLOPROPYL UNSATURATED QUINOLINE COMPOUND USED AS LEUKOTRIENE RECEPTOR ANTAGONIST AND APPLICATIONS THEREOF | GUANGDONG MOLTECH PHARMA CO., LTD. (CN) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190248746-A1 | CYCLOPROPYL UNSATURATED QUINOLINE COMPOUND USED AS LEUKOTRIENE RECEPTOR ANTAGONIST AND APPLICATIONS THEREOF | LTC4S, LTB4R, CYSLTR1 | POLB 3501/4885SOAT1 1436/4885ALDH1A1 1624/4885 |
| US-20180118687-A1 | CYCLOPROPYL UNSATURATED QUINOLINE COMPOUND USED AS LEUKOTRIENE RECEPTOR ANTAGONIST AND APPLICATIONS THEREOF | LTC4S, LTB4R, CYSLTR1 | POLB 3551/4885SOAT1 1419/4885ALDH1A1 1566/4885 |
| US-10315997-B2 | Cyclopropyl unsaturated quinoline compound used as leukotriene receptor antagonist and applications thereof | LTC4S, LTB4R, CYSLTR1 | POLB 3551/4885SOAT1 1419/4885ALDH1A1 1566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.