Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007650 | 0.76 | POLB (0.39) | POLBALDH1A1KDM4EGAA | |
| SCHEMBL2010191 | 0.73 | PDK1 (0.50) | GPR119SLC6A4HDAC1 | |
| SCHEMBL3131491 | 0.71 | MGLL (0.44) | GPR119 | |
| SCHEMBL1703971 | 0.71 | ALDH1A1 (0.51) | POLBALDH1A1KDM4ECHRM2CHRM3 | |
| SCHEMBL14813528 | 0.71 | ALDH1A1 (0.45) | OPRD1OPRK1NR1H2NR1H3ACHE | |
| SCHEMBL1703908 | 0.70 | ALDH1A1 (0.43) | POLBALDH1A1KDM4EHDAC1 | |
| SCHEMBL1633895 | 0.70 | KDM4E (0.51) | POLBALDH1A1KDM4EMAPT | |
| SCHEMBL12878388 | 0.70 | CYP4F2 (0.43) | POLBNR1H2NR1H3MAPTHDAC1 | |
| SCHEMBL1188920 | 0.69 | MEN1 (0.48) | ALDH1A1KDM4EGAA | |
| SCHEMBL14085918 | 0.68 | NPFFR1 (0.47) | OPRD1OPRK1ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964602-B2 | Biaryl compounds useful as agonists of the Gpr38 receptor | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |