Sugi Predict

Sugi Predict / Compounds / SCHEMBL2010267

SCHEMBL2010267

SCHEMBL2010267

CC(=O)c1ccc(C(=O)Cl)c(C)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2A6 P11509 1/20 0.46
▸ MAPT P10636 4/20 0.42
▸ RAB9A P51151 3/20 0.42
▸ NPC1 O15118 2/20 0.42
▸ AKR1C3 P42330 6/20 0.41
▸ AKR1C2 P52895 6/20 0.41
▸ AKR1B10 O60218 1/20 0.41
▸ AKR1B1 P15121 1/20 0.41
▸ AKR1C4 P17516 1/20 0.41
▸ AKR1C1 Q04828 1/20 0.41
▸ HSD17B1 P14061 1/20 0.41
▸ PKM P14618 1/20 0.40
▸ HPGD P15428 3/20 0.39
▸ PRKCI P41743 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ S100A4 P26447 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ CHRNA1 P02708 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31634804 0.87 CES2 (0.39) MAPTNPC1ALDH1A1LMNAKMT2A
SCHEMBL1773780 0.87 CES2 (0.39) MAPTNPC1ALDH1A1LMNAKMT2A
SCHEMBL21985528 0.83 SMN1; SMN2 (0.39) CYP2A6MAPTRAB9ANPC1HSD17B1
SCHEMBL5383734 0.83 TSHR (0.50) MAPTALDH1A1L3MBTL1KMT2ASMN1; SMN2
SCHEMBL28588206 0.82 PKM (0.47) CYP2A6MAPTRAB9ANPC1AKR1C3
SCHEMBL2012610 0.81 AKR1C3 (0.54) CYP2A6AKR1C3AKR1C2AKR1B10AKR1B1
SCHEMBL107882 0.81 FLT1 (0.51) MAPTRAB9ANPC1ALDH1A1KMT2A
SCHEMBL2154184 0.79 ALDH1A1 (0.37) CYP2A6MAPTHSD17B1HPGDALDH1A1
Hydrochloric Acid SCHEMBL2010269 0.79 AKR1C3 (0.53) CYP2A6AKR1C3AKR1C2AKR1B10AKR1B1
SCHEMBL3359193 0.79 MKNK1 (0.46) CYP2A6MAPTRAB9ANPC1AKR1C3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117510428-A Preparation process method of isoxazoline substituted benzamide compound 中国农业大学 2024-02-06 — — CN claimed
CN-122036557-A Cycloserine intermediate and application thereof 山东潍坊润丰化工股份有限公司 2026-05-15 — — CN disclosed
CN-117510428-A Preparation process method of isoxazoline substituted benzamide compound 中国农业大学 2024-02-06 — — CN disclosed
CN-113896690-B Preparation method of isoxazoline anthelmintic fluorine Lei Lana 常州齐晖药业有限公司 2023-04-21 — — CN disclosed
US-11357231-B2 Insecticidal compounds based on isoxazoline derivatives SYNGENTA CROP PROTECTION LLC (US) 2022-06-14 — — US disclosed
CN-114315748-A Synthesis method of flurarana 江苏天和制药有限公司 2022-04-12 — — CN disclosed
CN-114031572-A Process for preparing substituted cycloserines 先正达参股股份有限公司 2022-02-11 — — CN disclosed
CN-113896690-A Preparation method of isoxazoline anthelmintic agent fluranide 常州齐晖药业有限公司 2022-01-07 — — CN disclosed
CN-108026090-B Isoxazoline substituted benzamides and analogs as pesticides 先正达参股股份有限公司 2021-10-26 — — CN disclosed
CN-108026089-B Isoxazoline substituted benzamides and analogs as pesticides 先正达参股股份有限公司 2021-10-22 — — CN disclosed
US-20140206633-A1 PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES SYNGENTA CROP PROTECTION LLC (US) 2014-07-24 — — US disclosed
US-20140206633-A1 PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES SYNGENTA CROP PROTECTION LLC (US) 2014-07-24 — — US disclosed
US-8735362-B2 Insecticidal compounds based on isoxazoline derivatives SYNGENTA CROP PROTECTION, LLC (US) 2014-05-27 — — US disclosed
EP-2539335-A1 PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES Syngenta Participations AG (CH) 2013-01-02 — — EP disclosed
CN-102822168-A Method for producing isoxazoline derivatives SYNGENTA PARTICIPATIONS AG 2012-12-12 — — CN disclosed
EP-2507230-A1 INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES Syngenta Participations AG (CH) 2012-10-10 — — EP disclosed
US-20120238517-A1 INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES SYNGENTA CROP PROTECTION LLC (US) 2012-09-20 — — US disclosed
WO-2011104089-A1 PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2011-09-01 — — WO disclosed
WO-2011104089-A1 PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2011-09-01 — — WO disclosed
WO-2011067272-A1 INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2011-06-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120238517-A1 INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES CHRM1, ACHE, CHRM2 CYP2A6 2287/4885MAPT 3091/4885RAB9A 265/4885
US-11357231-B2 Insecticidal compounds based on isoxazoline derivatives CYP4X1, NPY4R, CASP3 CYP2A6 644/4885MAPT 3621/4885RAB9A 611/4885
US-20140206633-A1 PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES CYP1A2, CHRM1, CYP1A1 CYP2A6 149/4885MAPT 3619/4885RAB9A 2340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.