Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 13/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 13/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.54 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2010269 | 0.98 | AKR1C3 (0.53) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL44342 | 0.86 | MYC (0.58) | ALDH1A1RXRBRXRAMYC | |
| SCHEMBL29399874 | 0.86 | MYC (0.58) | ALDH1A1RXRBRXRAMYC | |
| SCHEMBL12132604 | 0.85 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL11454527 | 0.84 | MYC (0.61) | ALDH1A1RXRBRXRAMYC | |
| Water SCHEMBL3832510 | 0.84 | MYC (0.56) | ALDH1A1RXRBRXRAMYC | |
| SCHEMBL11881710 | 0.84 | MYC (0.56) | ALDH1A1RXRBRXRAMYC | |
| Hydrochloric Acid SCHEMBL3169435 | 0.84 | MYC (0.56) | ALDH1A1RXRBRXRAMYC | |
| Ammonia Solution, Strong SCHEMBL11877008 | 0.84 | MYC (0.56) | ALDH1A1RXRBRXRAMYC | |
| SCHEMBL10876187 | 0.84 | MYC (0.56) | ALDH1A1RXRBRXRAMYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 167 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122059897-A | Synthesis method of fluorine Lei Lana derivative | 济南久隆医药科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-119977901-A | Telescoping process method for preparing fluorine Lei Lana | 湖南九维生物医药有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119874502-A | Method for producing 2-methyl-4-acetylbenzoic acid | 帕潘纳(北京)科技有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-119751370-A | Preparation method of fluororalrana | 河北威远药业有限公司 | 2025-04-04 | — | — | CN | claimed |
| CN-118878475-A | Isoxazoline-containing amide compound and preparation method and application thereof | 江西众和化工有限公司 | 2024-11-01 | — | — | CN | claimed |
| CN-118561677-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 丽珠集团福州福兴医药有限公司 | 2024-08-30 | — | — | CN | claimed |
| CN-118324623-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 丽珠集团福州福兴医药有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-115477577-B | New method for preparing 2-methyl-4-acetyl benzoic acid and derivatives thereof | 台州臻挚生物科技有限公司 | 2024-03-15 | — | — | CN | claimed |
| CN-115677605-B | Preparation method of S-configuration-fluorine Lei Lana | 瑞普（天津）生物药业有限公司 | 2024-02-27 | — | — | CN | claimed |
| CN-117186022-A | Method for efficiently synthesizing fluororalrana | 内蒙古联邦动保药品有限公司 | 2023-12-08 | — | — | CN | claimed |
| CN-117186023-A | Preparation method of high-purity fluorine Lei Lana | 河北圣雪大成制药有限责任公司 | 2023-12-08 | — | — | CN | claimed |
| CN-116987042-A | Synthesis method of fluororalrana | 杭州丰禧生物科技有限公司 | 2023-11-03 | — | — | CN | claimed |
| CN-116640100-A | Solid-phase synthesis method of fluororalrana | 河北圣雪大成制药有限责任公司 | 2023-08-25 | — | — | CN | claimed |
| CN-116478057-A | Preparation method of fluororalrana intermediate | 洛阳惠中兽药有限公司 | 2023-07-25 | — | — | CN | claimed |
| CN-116217372-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 南京杰运医药科技有限公司 | 2023-06-06 | — | — | CN | claimed |
| CN-115677605-A | Preparation method of S-shaped fluorine Lei Lana | 瑞普（天津）生物药业有限公司 | 2023-02-03 | — | — | CN | claimed |
| CN-115477577-A | Novel method for preparing 2-methyl-4-acetylbenzoic acid and derivatives thereof | 台州臻挚生物科技有限公司 | 2022-12-16 | — | — | CN | claimed |
| CN-114315748-A | Synthesis method of flurarana | 江苏天和制药有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-109553528-A | A kind of synthetic method of 2- methyl -4- acetylbenzoic acid methyl esters | 荆门医药工业技术研究院 | 2019-04-02 | — | — | CN | claimed |
| CN-122059897-A | Synthesis method of fluorine Lei Lana derivative | 济南久隆医药科技有限公司 | 2026-05-19 | — | — | CN | disclosed |
| CN-122059897-A | Synthesis method of fluorine Lei Lana derivative | 济南久隆医药科技有限公司 | 2026-05-19 | — | — | CN | disclosed |
| CN-121895145-A | Preparation process of 2-methyl-4-acetyl benzoic acid | 上海筑裕新材料科技有限公司 | 2026-04-21 | — | — | CN | disclosed |
| CN-121895145-A | Preparation process of 2-methyl-4-acetyl benzoic acid | 上海筑裕新材料科技有限公司 | 2026-04-21 | — | — | CN | disclosed |
| CN-121378165-A | Preparation method of fluororalrana N-1 intermediate | 湖北赤壁集技产业技术研究院有限公司 | 2026-01-23 | — | — | CN | disclosed |
| CN-117186023-B | Preparation method of high-purity fluorine Lei Lana | 河北圣雪大成制药有限责任公司 | 2026-01-20 | — | — | CN | disclosed |
| CN-120843616-A | Biocatalysis method for synthesizing 4-acetyl-2-methylbenzoic acid based on 4-acetyl-2-methylbenzonitrile | 常州大学 | 2025-10-28 | — | — | CN | disclosed |
| CN-120843616-A | Biocatalysis method for synthesizing 4-acetyl-2-methylbenzoic acid based on 4-acetyl-2-methylbenzonitrile | 常州大学 | 2025-10-28 | — | — | CN | disclosed |
| CN-120554217-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 丽珠集团福州福兴医药有限公司 | 2025-08-29 | — | — | CN | disclosed |
| CN-120554217-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 丽珠集团福州福兴医药有限公司 | 2025-08-29 | — | — | CN | disclosed |
| CN-120383525-A | Preparation method of 2-methyl-4-acetyl benzoic acid | 潍坊市海欣药业有限公司 | 2025-07-29 | — | — | CN | disclosed |
| CN-120383525-A | Preparation method of 2-methyl-4-acetyl benzoic acid | 潍坊市海欣药业有限公司 | 2025-07-29 | — | — | CN | disclosed |
| CN-116987042-B | Synthesis method of fluororalrana | 杭州丰禧生物科技有限公司 | 2025-07-15 | — | — | CN | disclosed |
| CN-120230056-A | Synthesis method of fluororalrana | 湖南华腾制药有限公司 | 2025-07-01 | — | — | CN | disclosed |
| CN-116425693-B | Preparation method of fluorine Lei Lana, novel crystal form of fluorine ralfinade, preparation method and application thereof | 洛阳惠中兽药有限公司 | 2025-06-13 | — | — | CN | disclosed |
| WO-2025108463-A1 | ISOXAZOLINE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 山东康乔生物科技有限公司 | 2025-05-30 | — | — | WO | disclosed |
| CN-120040365-A | Isoxazoline compound and preparation method and application thereof | 山东康乔生物科技有限公司 | 2025-05-27 | — | — | CN | disclosed |
| CN-119977901-A | Telescoping process method for preparing fluorine Lei Lana | 湖南九维生物医药有限公司 | 2025-05-13 | — | — | CN | disclosed |
| CN-119977901-A | Telescoping process method for preparing fluorine Lei Lana | 湖南九维生物医药有限公司 | 2025-05-13 | — | — | CN | disclosed |
| CN-119874502-A | Method for producing 2-methyl-4-acetylbenzoic acid | 帕潘纳(北京)科技有限公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-119874502-A | Method for producing 2-methyl-4-acetylbenzoic acid | 帕潘纳(北京)科技有限公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-119874502-A | Method for producing 2-methyl-4-acetylbenzoic acid | 帕潘纳(北京)科技有限公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-119798069-A | Preparation method of fluororalrana intermediate impurity | 兰西哈三联制药有限公司 | 2025-04-11 | — | — | CN | disclosed |
| CN-119751370-A | Preparation method of fluororalrana | 河北威远药业有限公司 | 2025-04-04 | — | — | CN | disclosed |
| CN-119707847-A | Gamma-aminobutyric acid gated chloride ion channel allosteric modulator compound and application thereof | 山东德浩化学有限公司 | 2025-03-28 | — | — | CN | disclosed |
| US-20250091998-A1 | A PROCESS FOR THE PREPARATION OF CARBAMOYL BENZAMIDE PHENYL ISOXAZOLINE CLASS DRUG/S AND ITS INTERMEDIATES | ZENFOLD SUSTAINABLE TECHNOLOGIES PRIVATE LIMITED (IN) | 2025-03-20 | — | — | US | disclosed |
| CN-117384028-B | Synthesis method of 4-acetyl-1-naphthoic acid | 济南久隆医药科技有限公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-118878475-B | Isoxazoline-containing amide compound and preparation method and application thereof | 江西众和化工有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-118878475-A | Isoxazoline-containing amide compound and preparation method and application thereof | 江西众和化工有限公司 | 2024-11-01 | — | — | CN | disclosed |
| CN-114591259-B | Preparation of isoxazole compounds | 江苏慧聚药业股份有限公司 | 2024-10-22 | — | — | CN | disclosed |
| WO-2024201231-A1 | A PROCESS FOR THE PREPARATION OF ISOXAZOLINE-SUBSTITUTED AMIDE COMPOUNDS AND ITS INTERMEDIATES THEREOF | HIKAL LIMITED (IN) | 2024-10-03 | — | — | WO | disclosed |
| CN-118561677-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 丽珠集团福州福兴医药有限公司 | 2024-08-30 | — | — | CN | disclosed |
| CN-118561677-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 丽珠集团福州福兴医药有限公司 | 2024-08-30 | — | — | CN | disclosed |
| CN-118561677-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 丽珠集团福州福兴医药有限公司 | 2024-08-30 | — | — | CN | disclosed |
| US-12065414-B2 | Process for preparation of isoxazoline substituted benzamide compound | ZYDUS LIFESCIENCES LIMITED (IN) | 2024-08-20 | — | — | US | disclosed |
| CN-118324623-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 丽珠集团福州福兴医药有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-118324623-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 丽珠集团福州福兴医药有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-118324623-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 丽珠集团福州福兴医药有限公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-118047728-B | Preparation method of fluororalrana | 南京道尔医药研究院有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-118076600-A | Compound containing five-membered heterocycle, and preparation method and application thereof | 青岛康乔药业集团有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-118047728-A | Preparation method of fluororalrana | 南京道尔医药研究院有限公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-117886806-A | Five-membered heterocyclic compound containing sulfone, and preparation method and application thereof | 青岛康乔药业集团有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-117776924-A | Key intermediate of 4-acetyl-2-methylbenzoic acid and synthetic method thereof | 苏州楚凯药业有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-117776924-A | Key intermediate of 4-acetyl-2-methylbenzoic acid and synthetic method thereof | 苏州楚凯药业有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-117776924-A | Key intermediate of 4-acetyl-2-methylbenzoic acid and synthetic method thereof | 苏州楚凯药业有限公司 | 2024-03-29 | — | — | CN | disclosed |
| WO-2024061178-A1 | COMPOUND CONTAINING FIVE-MEMBERED HETEROCYCLE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 青岛康乔药业集团有限公司 | 2024-03-28 | — | — | WO | disclosed |
| CN-115477577-B | New method for preparing 2-methyl-4-acetyl benzoic acid and derivatives thereof | 台州臻挚生物科技有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-115477577-B | New method for preparing 2-methyl-4-acetyl benzoic acid and derivatives thereof | 台州臻挚生物科技有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-115477577-B | New method for preparing 2-methyl-4-acetyl benzoic acid and derivatives thereof | 台州臻挚生物科技有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-115677605-B | Preparation method of S-configuration-fluorine Lei Lana | 瑞普（天津）生物药业有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-115677605-B | Preparation method of S-configuration-fluorine Lei Lana | 瑞普（天津）生物药业有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-117510428-A | Preparation process method of isoxazoline substituted benzamide compound | 中国农业大学 | 2024-02-06 | — | — | CN | disclosed |
| CN-117402153-A | Compound containing fluorine and five-membered heterocycle, preparation method and application thereof | 青岛美嘉农业科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117384028-A | Synthesis method of 4-acetyl-1-naphthoic acid | 济南久隆医药科技有限公司 | 2024-01-12 | — | — | CN | disclosed |
| CN-117186022-A | Method for efficiently synthesizing fluororalrana | 内蒙古联邦动保药品有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-117186023-A | Preparation method of high-purity fluorine Lei Lana | 河北圣雪大成制药有限责任公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-117186023-A | Preparation method of high-purity fluorine Lei Lana | 河北圣雪大成制药有限责任公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-116987042-A | Synthesis method of fluororalrana | 杭州丰禧生物科技有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-116987042-A | Synthesis method of fluororalrana | 杭州丰禧生物科技有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-116640100-A | Solid-phase synthesis method of fluororalrana | 河北圣雪大成制药有限责任公司 | 2023-08-25 | — | — | CN | disclosed |
| CN-116606260-A | Synthesis method of fluorine Lei Lana | 丽珠集团福州福兴医药有限公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-116478057-A | Preparation method of fluororalrana intermediate | 洛阳惠中兽药有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-116478057-A | Preparation method of fluororalrana intermediate | 洛阳惠中兽药有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-116425693-A | Preparation method of fluorine Lei Lana, novel crystal form of fluorine ralfinade, preparation method and application thereof | 洛阳惠中兽药有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-116217372-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 南京杰运医药科技有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-116217372-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 南京杰运医药科技有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-116217372-A | Synthesis method of 2-methyl-4-acetyl benzoic acid | 南京杰运医药科技有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-113896690-B | Preparation method of isoxazoline anthelmintic fluorine Lei Lana | 常州齐晖药业有限公司 | 2023-04-21 | — | — | CN | disclosed |
| WO-2023012821-A1 | A PROCESS FOR THE PREPARATION OF CARBAMOYL BENZAMIDE PHENYL ISOXAZOLINE CLASS DRUG/S AND ITS INTERMEDIATES | ZENFOLD SUSTAINABLE TECHNOLOGIES PRIVATE LIMITED (IN) | 2023-02-09 | — | — | WO | disclosed |
| CN-115677605-A | Preparation method of S-shaped fluorine Lei Lana | 瑞普（天津）生物药业有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115677605-A | Preparation method of S-shaped fluorine Lei Lana | 瑞普（天津）生物药业有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115477577-A | Novel method for preparing 2-methyl-4-acetylbenzoic acid and derivatives thereof | 台州臻挚生物科技有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-115477577-A | Novel method for preparing 2-methyl-4-acetylbenzoic acid and derivatives thereof | 台州臻挚生物科技有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-115477577-A | Novel method for preparing 2-methyl-4-acetylbenzoic acid and derivatives thereof | 台州臻挚生物科技有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-114957147-A | Preparation method of isoxazoline derivatives | 武汉工程大学 | 2022-08-30 | — | — | CN | disclosed |
| EP-4021897-A1 | ISOXAZOLINE COMPOUNDS AND THEIR USE AS PEST CONTROL AGENTS | PI Industries Ltd. (IN) | 2022-07-06 | — | — | EP | disclosed |
| US-11357231-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION LLC (US) | 2022-06-14 | — | — | US | disclosed |
| CN-114591259-A | Preparation of isoxazole compounds | 江苏慧聚药业股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-112694449-B | Asymmetric hydrogenation of ketone and alpha, beta-unsaturated ketone catalyzed by nonmetal catalyst | 中国科学院化学研究所 | 2022-05-24 | — | — | CN | disclosed |
| CN-114315748-A | Synthesis method of flurarana | 江苏天和制药有限公司 | 2022-04-12 | — | — | CN | disclosed |
| US-20220064130-A1 | PROCESS FOR PREPARATION OF ISOXAZOLINE SUBSTITUTED BENZAMIDE COMPOUND | ZYDUS LIFESCIENCES LIMITED (IN) | 2022-03-03 | — | — | US | disclosed |
| CN-114031572-A | Process for preparing substituted cycloserines | 先正达参股股份有限公司 | 2022-02-11 | — | — | CN | disclosed |
| CN-113896690-A | Preparation method of isoxazoline anthelmintic agent fluranide | 常州齐晖药业有限公司 | 2022-01-07 | — | — | CN | disclosed |
| CN-113512007-A | Synthesis of flurarana | 江苏君若药业有限公司 | 2021-10-19 | — | — | CN | disclosed |
| WO-2021105840-A1 | PROCESS FOR PURIFICATION OF FLURALANER | HIKAL LIMITED (IN) | 2021-06-03 | — | — | WO | disclosed |
| WO-2021105840-A1 | PROCESS FOR PURIFICATION OF FLURALANER | HIKAL LIMITED (IN) | 2021-06-03 | — | — | WO | disclosed |
| CN-112694449-A | Novel nonmetal catalyst for catalyzing asymmetric hydrogenation of ketone and alpha, beta-unsaturated ketone | 中国科学院化学研究所 | 2021-04-23 | — | — | CN | disclosed |
| WO-2021038501-A1 | ISOXAZOLINE COMPOUNDS AND THEIR USE AS PEST CONTROL AGENTS | PI INDUSTRIES LTD. (IN) | 2021-03-04 | — | — | WO | disclosed |
| EP-3762367-A1 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI Industries Ltd. (IN) | 2021-01-13 | — | — | EP | disclosed |
| US-20210002232-A1 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI INDUSTRIES LTD. (IN) | 2021-01-07 | — | — | US | disclosed |
| US-20200383330-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2020-12-10 | — | — | US | disclosed |
| US-10750745-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2020-08-25 | — | — | US | disclosed |
| EP-3094626-B1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2020-02-19 | — | — | EP | disclosed |
| WO-2019171234-A9 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI INDUSTRIES LTD. (IN) | 2020-01-09 | — | — | WO | disclosed |
| WO-2019171234-A1 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI INDUSTRIES LTD. (IN) | 2019-09-12 | — | — | WO | disclosed |
| US-20190166842-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2019-06-06 | — | — | US | disclosed |
| CN-109553528-A | A kind of synthetic method of 2- methyl -4- acetylbenzoic acid methyl esters | 荆门医药工业技术研究院 | 2019-04-02 | — | — | CN | disclosed |
| CN-109553528-A | A kind of synthetic method of 2- methyl -4- acetylbenzoic acid methyl esters | 荆门医药工业技术研究院 | 2019-04-02 | — | — | CN | disclosed |
| US-10206400-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2019-02-19 | — | — | US | disclosed |
| EP-2507230-B1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2018-01-17 | — | — | EP | disclosed |
| US-9862713-B2 | Substituted bicyclic heteroaryl compounds as RXR agonists | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2018-01-09 | — | — | US | disclosed |
| US-9815803-B2 | Process for the preparation of substituted cycloserines | SYNGENTA PARTICIPATIONS AG (CH) | 2017-11-14 | — | — | US | disclosed |
| US-9751821-B1 | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2017-09-05 | — | — | US | disclosed |
| US-20170233321-A1 | METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND, METHOD FOR PRODUCTION OF 2-PROPEN-1-ONE COMPOUND AND METHOD FOR PRODUCTION OF ISOXAZOLINE COMPOUND | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2017-08-17 | — | — | US | disclosed |
| US-20170204072-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYCLOSERINES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-07-20 | — | — | US | disclosed |
| US-9676692-B2 | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2017-06-13 | — | — | US | disclosed |
| US-20170152250-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2017-06-01 | — | — | US | disclosed |
| US-9643938-B2 | Process for the preparation of substituted cycloserines | SYNGENTA PARTICIPATIONS AG (CH) | 2017-05-09 | — | — | US | disclosed |
| US-9609869-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2017-04-04 | — | — | US | disclosed |
| EP-3137449-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYCLOSERINES | Syngenta Participations AG (CH) | 2017-03-08 | — | — | EP | disclosed |
| US-20170044116-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYCLOSERINES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-02-16 | — | — | US | disclosed |
| EP-2539335-B1 | PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-12-21 | — | — | EP | disclosed |
| EP-2539335-B1 | PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-12-21 | — | — | EP | disclosed |
| EP-3094626-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS | Connexios Life Sciences Pvt. Ltd. (IN) | 2016-11-23 | — | — | EP | disclosed |
| US-20160333004-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2016-11-17 | — | — | US | disclosed |
| WO-2015166094-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYCLOSERINES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-11-05 | — | — | WO | disclosed |
| CN-102639529-B | Isoxazoline derivative-based pesticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2015-08-19 | — | — | CN | disclosed |
| WO-2015107549-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2015-07-23 | — | — | WO | disclosed |
| US-20150119576-A1 | METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND, METHOD FOR PRODUCTION OF 2-PROPEN-1-ONE COMPOUND AND METHOD FOR PRODUCTION OF ISOXAZOLINE COMPOUND | NISSAN CHEMICAL CORPORATION (JP) | 2015-04-30 | — | — | US | disclosed |
| US-8952175-B2 | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2015-02-10 | — | — | US | disclosed |
| US-20140228577-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2014-08-14 | — | — | US | disclosed |
| US-20140206633-A1 | PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2014-07-24 | — | — | US | disclosed |
| US-20140206633-A1 | PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2014-07-24 | — | — | US | disclosed |
| US-20140206633-A1 | PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2014-07-24 | — | — | US | disclosed |
| US-8735362-B2 | Insecticidal compounds based on isoxazoline derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2014-05-27 | — | — | US | disclosed |
| CN-103764644-A | Isoxazoline derivatives as pesticidal compounds | SYNGENTA PARTICIPATIONS AG | 2014-04-30 | — | — | CN | disclosed |
| US-8426441-B2 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC (US) | 2013-04-23 | — | — | US | disclosed |
| US-8372867-B2 | Insecticidal aryl isoxazoline derivatives | BAYER CROPSCIENCE AG (DE) | 2013-02-12 | — | — | US | disclosed |
| EP-2539335-A1 | PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES | Syngenta Participations AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| CN-102822168-A | Method for producing isoxazoline derivatives | SYNGENTA PARTICIPATIONS AG | 2012-12-12 | — | — | CN | disclosed |
| EP-2507230-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | Syngenta Participations AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| US-20120238517-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES | SYNGENTA CROP PROTECTION LLC (US) | 2012-09-20 | — | — | US | disclosed |
| CN-102639529-A | Isoxazoline derivative-based pesticidal compounds | SYNGENTA PARTICIPATIONS AG | 2012-08-15 | — | — | CN | disclosed |
| WO-2011104089-A1 | PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011104089-A1 | PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-09-01 | — | — | WO | disclosed |
| WO-2011067272-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-09 | — | — | WO | disclosed |
| EP-2229390-A1 | NOVEL IMIDAZOÝ1,2-A¨PYRIDINE AND IMIDAZOÝ1,2-B¨PYRIDAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| US-20100179194-A1 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | BAYER CORPSCIENCE AG (DE) | 2010-07-15 | — | — | US | disclosed |
| US-20100137612-A1 | METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND FOR PRODUCTION OF 2- PROPEN-1-ONE COMPOUND AND METHOD FOR PRODUCTION OF ISOXAZLINE COMPOUND | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-06-03 | — | — | US | disclosed |
| EP-2181100-A2 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | Bayer CropScience AG (DE) | 2010-05-05 | — | — | EP | disclosed |
| EP-2172462-A1 | METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND, METHOD FOR PRODUCTION OF 2-PROPEN-1-ONE COMPOUND, AND METHOD FOR PRODUCTION OF ISOXAZOLINE COMPOUND | Nissan Chemical Industries, Ltd. (JP) | 2010-04-07 | — | — | EP | disclosed |
| US-20090186898-A1 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC | 2009-07-23 | — | — | US | disclosed |
| WO-2009077334-A1 | NOVEL IMIDAZO[1,2-A]PYRIDINE AND IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |
| WO-2008122375-A2 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2008-10-16 | — | — | WO | disclosed |
| US-7300934-B2 | Benzamide nitriles | ROCHE PALO ALTO LLC (US) | 2007-11-27 | — | — | US | disclosed |
| EP-1633701-A1 | BENZAMIDE NITRILE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004106285-A1 | BENZAMIDE NITRILE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004106285-A1 | BENZAMIDE NITRILE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-09 | — | — | WO | disclosed |
| US-20040248949-A1 | Benzamide nitriles | ROCHE PALO ALTO LLC | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (22 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119576-A1 | METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND, METHOD FOR PRODUCTION OF 2-PROPEN-1-ONE COMPOUND AND METHOD FOR PRODUCTION OF ISOXAZOLINE COMPOUND | ADH1C, ADH1A, CYP2E1 | AKR1C3 19/4885AKR1C2 49/4885AKR1B10 70/4885 |
| US-20090186898-A1 | Inhibitors of bruton's tyrosine kinase | BTK, SYK, LYN | AKR1C3 2731/4885AKR1C2 2660/4885AKR1B10 2739/4885 |
| US-20100137612-A1 | METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND FOR PRODUCTION OF 2- PROPEN-1-ONE COMPOUND AND METHOD FOR PRODUCTION OF ISOXAZLINE COMPOUND | ADH1C, CYP2E1, ADH1A | AKR1C3 43/4885AKR1C2 82/4885AKR1B10 90/4885 |
| US-20100179194-A1 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | CYP4X1, AADAC, CYP3A7 | AKR1C3 587/4885AKR1C2 345/4885AKR1B10 927/4885 |
| US-20140228577-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | AKR1C3 191/4885AKR1C2 623/4885AKR1B10 1122/4885 |
| US-20210002232-A1 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | CYP1A2, CYP1B1, CYP1A1 | AKR1C3 261/4885AKR1C2 491/4885AKR1B10 802/4885 |
| US-20170044116-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYCLOSERINES | C1S, C1R, C5 | AKR1C3 58/4885AKR1C2 242/4885AKR1B10 350/4885 |
| US-12065414-B2 | Process for preparation of isoxazoline substituted benzamide compound | CYP3A7, CYP3A4, CYP4X1 | AKR1C3 524/4885AKR1C2 428/4885AKR1B10 776/4885 |
| US-20200383330-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CYP4X1, NPY4R, CASP3 | AKR1C3 1254/4885AKR1C2 2377/4885AKR1B10 3003/4885 |
| US-20120238517-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | AKR1C3 90/4885AKR1C2 346/4885AKR1B10 881/4885 |
| US-20250091998-A1 | A PROCESS FOR THE PREPARATION OF CARBAMOYL BENZAMIDE PHENYL ISOXAZOLINE CLASS DRUG/S AND ITS INTERMEDIATES | CYP3A7, CYP1A2, CYP1B1 | AKR1C3 618/4885AKR1C2 482/4885AKR1B10 1087/4885 |
| US-10206400-B2 | Insecticidal compounds based on isoxazoline derivatives | CHRM1, ACHE, CHRM2 | AKR1C3 191/4885AKR1C2 623/4885AKR1B10 1122/4885 |
| US-11357231-B2 | Insecticidal compounds based on isoxazoline derivatives | CYP4X1, NPY4R, CASP3 | AKR1C3 1254/4885AKR1C2 2377/4885AKR1B10 3003/4885 |
| US-20170152250-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | AKR1C3 191/4885AKR1C2 623/4885AKR1B10 1122/4885 |
| US-20170204072-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED CYCLOSERINES | C1S, C1R, C5 | AKR1C3 31/4885AKR1C2 143/4885AKR1B10 245/4885 |
| US-20140206633-A1 | PROCESS FOR THE PREPARATION OF ISOXAZOLINE DERIVATIVES | CYP1A2, CHRM1, CYP1A1 | AKR1C3 196/4885AKR1C2 325/4885AKR1B10 568/4885 |
| US-10750745-B2 | Insecticidal compounds based on isoxazoline derivatives | CHRM1, ACHE, CHRM2 | AKR1C3 191/4885AKR1C2 623/4885AKR1B10 1122/4885 |
| US-20040248949-A1 | Benzamide nitriles | CTSK, CTSS, CMA1 | AKR1C3 532/4885AKR1C2 604/4885AKR1B10 344/4885 |
| US-20160333004-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS | RXRA, RXRB, RXRG | AKR1C3 302/4885AKR1C2 377/4885AKR1B10 616/4885 |
| US-20170233321-A1 | METHOD FOR PRODUCTION OF 3-HYDROXYPROPAN-1-ONE COMPOUND, METHOD FOR PRODUCTION OF 2-PROPEN-1-ONE COMPOUND AND METHOD FOR PRODUCTION OF ISOXAZOLINE COMPOUND | ADH1C, ADH1A, CYP2E1 | AKR1C3 19/4885AKR1C2 49/4885AKR1B10 70/4885 |
| US-20190166842-A1 | INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES | CHRM1, ACHE, CHRM2 | AKR1C3 191/4885AKR1C2 623/4885AKR1B10 1122/4885 |
| US-20220064130-A1 | PROCESS FOR PREPARATION OF ISOXAZOLINE SUBSTITUTED BENZAMIDE COMPOUND | CYP3A7, CYP3A4, CYP4X1 | AKR1C3 524/4885AKR1C2 428/4885AKR1B10 776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.