Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.67 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20103600 | 0.89 | EPHX2 (0.63) | ALOX5EPHX2ALOX5APAURKBAGPAT2 | |
| SCHEMBL7542425 | 0.83 | ALOX5 (0.48) | ALOX5EPHX2ALOX5APKDRMEN1 | |
| SCHEMBL7541413 | 0.82 | LMNA (0.47) | ALOX5EPHX2ALOX5APKDRAGPAT2 | |
| SCHEMBL20103473 | 0.80 | ALOX5 (0.67) | ALOX5EPHX2ALOX5APMEN1NPC1 | |
| SCHEMBL20103602 | 0.80 | EPHX2 (1.00) | ALOX5EPHX2ALOX5AP | |
| SCHEMBL7548682 | 0.78 | RAB9A (0.52) | ALOX5EPHX2ALOX5APAGPAT2MEN1 | |
| SCHEMBL7545865 | 0.77 | AGPAT2 (0.49) | ALOX5EPHX2ALOX5APKDRAGPAT2 | |
| SCHEMBL7541140 | 0.74 | LMNA (0.53) | ALOX5EPHX2AGPAT2KDM4EMEN1 | |
| SCHEMBL7545416 | 0.74 | RORC (0.55) | AGPAT2KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL7544792 | 0.74 | AGPAT2 (0.51) | ALOX5EPHX2AGPAT2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018077898-A1 | N,N'-DIARYLUREA, N,N'-DIARYLTHIOUREA AND N,N'-DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE | UNIVERSITÄT INNSBRUCK (AT) | 2018-05-03 | — | — | WO | disclosed |
| EP-3315495-A1 | N,N' -DIARYLUREA, N,N' -DIARYLTHIOUREA AND N,N' -DIARYLGUANIDINO COMPOUNDS FOR USE IN TREATMENT AND PREVENTION OF INFLAMMATORY DISEASE | Universität Innsbruck (AT) | 2018-05-02 | — | — | EP | disclosed |