SCHEMBL2010382

SCHEMBL2010382

CCC(c1ccccc1/C=C/C(N)=O)[Si](OC)(OC)OC

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS3 P29474 2/20 0.40
NOS1 P29475 2/20 0.40
NOS2 P35228 2/20 0.40
MAP3K7 O43318 5/20 0.40
TAB1 Q15750 5/20 0.40
LMNA P02545 4/20 0.39
HPGD P15428 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
PTPN1 P18031 2/20 0.38
NFE2L2 Q16236 2/20 0.38
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 1/20 0.38
ALOX12 P18054 1/20 0.38
KMT2A Q03164 1/20 0.38
TFEB P19484 1/20 0.36
KDM4E B2RXH2 2/20 0.35
MCL1 Q07820 1/20 0.35
CCNC P24863 1/20 0.34
CDK8 P49336 1/20 0.34
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5269733 0.88 KDM4E (0.46) NOS3NOS1NOS2LMNAHPGD
SCHEMBL14890280 0.83 MAPT (0.42) MAP3K7TAB1HPGDSMN1; SMN2MEN1
SCHEMBL14890279 0.83 MAPT (0.42) MAP3K7TAB1HPGDSMN1; SMN2MEN1
SCHEMBL10697312 0.77 PTPN1 (0.46) MAP3K7TAB1LMNAHPGDPTPN1
SCHEMBL2007943 0.76 IRAK4 (0.44) LMNAHPGDSMN1; SMN2MEN1ALDH1A1
SCHEMBL2010385 0.76 BCHE (0.43) NOS3NOS1NOS2LMNAHPGD
SCHEMBL1639304 0.74 TSHR (0.42) LMNAMEN1KMT2AKDM4E
SCHEMBL14890417 0.72 ALDH1A1 (0.41) SMN1; SMN2MEN1ALDH1A1KMT2AKDM4E
SCHEMBL14890413 0.72 ALDH1A1 (0.41) SMN1; SMN2MEN1ALDH1A1KMT2AKDM4E
SCHEMBL8161387 0.70 ALDH1A1 (0.40) NOS3NOS1NOS2SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1740152-B1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF SAIMDANG COSMETICS CO LTD (KR) 2012-12-26 EP claimed
US-7964747-B2 Poly(silsesquioxane) spherical particle containing ultraviolet light-absorbing group and manufacturing method thereof Saimdang Cosmetics, Co., Ltd. (KR) 2011-06-21 US claimed
US-20070249854-A1 Poly(Silsesquioxane) Spherical Particle Containing Ultraviolet Light-Absorbing Group and Manufacturing Method Thereof SAIMDANG COSMETICS CO., LTD. (KR) 2007-10-25 US claimed
EP-1740152-A1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF Saimdang Cosmetics Co., Ltd. (KR) 2007-01-10 EP claimed
WO-2005105028-A1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF SAIMDANG COSMETICS CO., LTD. (KR) 2005-11-10 WO claimed
EP-1740152-B1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF SAIMDANG COSMETICS CO LTD (KR) 2012-12-26 EP disclosed
US-7964747-B2 Poly(silsesquioxane) spherical particle containing ultraviolet light-absorbing group and manufacturing method thereof Saimdang Cosmetics, Co., Ltd. (KR) 2011-06-21 US disclosed
US-20070249854-A1 Poly(Silsesquioxane) Spherical Particle Containing Ultraviolet Light-Absorbing Group and Manufacturing Method Thereof SAIMDANG COSMETICS CO., LTD. (KR) 2007-10-25 US disclosed
EP-1740152-A1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF Saimdang Cosmetics Co., Ltd. (KR) 2007-01-10 EP disclosed
WO-2005105028-A1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF SAIMDANG COSMETICS CO., LTD. (KR) 2005-11-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249854-A1 Poly(Silsesquioxane) Spherical Particle Containing Ultraviolet Light-Absorbing Group and Manufacturing Method Thereof STS, PARG, SBDS NOS3 2825/4885NOS1 3095/4885NOS2 2950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.