SCHEMBL2010385

SCHEMBL2010385

CCC(c1ccc(C=CC(N)=O)cc1)[Si](OC)(OC)OC

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.43
ACHE P22303 1/20 0.43
PTGS2 P35354 1/20 0.43
TAS1R3 Q7RTX0 4/20 0.43
TAS1R1 Q7RTX1 4/20 0.43
ESR1 P03372 1/20 0.40
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 2/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
HPGD P15428 1/20 0.39
MAPK1 P28482 1/20 0.39
NOS3 P29474 3/20 0.38
NOS1 P29475 3/20 0.38
NOS2 P35228 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
LMNA P02545 1/20 0.38
GSK3B P49841 1/20 0.38
POLB P06746 1/20 0.37
F3 P13726 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5269742 0.87 KDM4E (0.54) BCHEACHEPTGS2TAS1R3TAS1R1
SCHEMBL17442501 0.76 CYP17A1 (0.34) ESR1LMNA
SCHEMBL2010382 0.76 NOS3 (0.40) PTGS2KDM4EALDH1A1HPGDNOS3
SCHEMBL20238791 0.74 ALDH1A1 (0.38) TAS1R3TAS1R1ALDH1A1
SCHEMBL3789520 0.73 MAPT (0.44) ALDH1A1HPGDMAPK1SMN1; SMN2CA1
SCHEMBL14890279 0.72 MAPT (0.42) TAS1R3TAS1R1KDM4EALDH1A1NPC1
SCHEMBL14890280 0.72 MAPT (0.42) TAS1R3TAS1R1KDM4EALDH1A1NPC1
SCHEMBL12894656 0.72 KDM4E (0.70) PTGS2KDM4EALDH1A1NPC1RAB9A
SCHEMBL1381805 0.72 KDM4E (0.70) PTGS2KDM4EALDH1A1NPC1RAB9A
SCHEMBL17888500 0.72 ESR1 (0.50) ESR1KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1740152-B1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF SAIMDANG COSMETICS CO LTD (KR) 2012-12-26 EP claimed
US-7964747-B2 Poly(silsesquioxane) spherical particle containing ultraviolet light-absorbing group and manufacturing method thereof Saimdang Cosmetics, Co., Ltd. (KR) 2011-06-21 US claimed
US-20070249854-A1 Poly(Silsesquioxane) Spherical Particle Containing Ultraviolet Light-Absorbing Group and Manufacturing Method Thereof SAIMDANG COSMETICS CO., LTD. (KR) 2007-10-25 US claimed
EP-1740152-A1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF Saimdang Cosmetics Co., Ltd. (KR) 2007-01-10 EP claimed
WO-2005105028-A1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF SAIMDANG COSMETICS CO., LTD. (KR) 2005-11-10 WO claimed
EP-1740152-B1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF SAIMDANG COSMETICS CO LTD (KR) 2012-12-26 EP disclosed
US-7964747-B2 Poly(silsesquioxane) spherical particle containing ultraviolet light-absorbing group and manufacturing method thereof Saimdang Cosmetics, Co., Ltd. (KR) 2011-06-21 US disclosed
US-20070249854-A1 Poly(Silsesquioxane) Spherical Particle Containing Ultraviolet Light-Absorbing Group and Manufacturing Method Thereof SAIMDANG COSMETICS CO., LTD. (KR) 2007-10-25 US disclosed
EP-1740152-A1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF Saimdang Cosmetics Co., Ltd. (KR) 2007-01-10 EP disclosed
WO-2005105028-A1 POLY(SILSESQUIOXANE) SPHERICAL PARTICLE CONTAINING ULTRAVIOLET LIGHT-ABSORBING GROUP AND MANUFACTURING METHOD THEREOF SAIMDANG COSMETICS CO., LTD. (KR) 2005-11-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249854-A1 Poly(Silsesquioxane) Spherical Particle Containing Ultraviolet Light-Absorbing Group and Manufacturing Method Thereof STS, PARG, SBDS BCHE 4104/4885ACHE 3112/4885PTGS2 1522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.