SCHEMBL2012496

SCHEMBL2012496

Cc1[c]cccc1-c1cccc(F)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.41
TAAR1 Q96RJ0 2/20 0.39
ESR2 Q92731 1/20 0.39
HTR1A P08908 1/20 0.38
HTR7 P34969 1/20 0.38
PGR P06401 1/20 0.37
TNKS2 Q9H2K2 1/20 0.36
MAOB P27338 1/20 0.36
MGAM O43451 1/20 0.36
GAA P10253 1/20 0.36
SI P14410 1/20 0.36
MGAM2 Q2M2H8 1/20 0.36
CDC7 O00311 1/20 0.36
ROCK2 O75116 1/20 0.36
MAP4K4 O95819 1/20 0.36
PIM1 P11309 1/20 0.36
PRKACA P17612 1/20 0.36
CDK2 P24941 1/20 0.36
GSK3B P49841 1/20 0.36
HIPK2 Q9H2X6 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2013153 0.87 HTR1A (0.35) ACHEHTR1AHTR7PGR
SCHEMBL3537988 0.81 ACHE (0.41) ACHEMAOBMAP4K4PIM1PRKACA
SCHEMBL7812113 0.81 TAAR1 (0.41) TAAR1ESR2HTR1AHTR7MAOB
SCHEMBL1996693 0.81 ACHE (0.39) ACHETAAR1ESR2HTR1AHTR7
SCHEMBL2014605 0.79 PTGS2 (0.42) ACHEHTR1AHTR7MAP4K4PRKACA
SCHEMBL2429097 0.79 TAAR1 (0.43) TAAR1ESR2HTR1AHTR7MAOB
SCHEMBL2432905 0.79 TGFBR1 (0.38) TNKS2MAOBNOTUM
SCHEMBL20956991 0.79 ESR2 (0.42) TAAR1ESR2HTR1AHTR7PGR
SCHEMBL4288525 0.79 HSD17B1 (0.45) ACHEESR2MAOBROCK2MAP4K4
SCHEMBL16719652 0.78 TUBB4A (0.40) TAAR1ESR2HTR1AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013182433-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-12-12 WO disclosed
EP-2547687-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2013-01-23 EP disclosed
EP-2513067-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2012-10-24 EP disclosed
WO-2011113820-A1 A PROCESS USING GRIGNARD REAGENTS BASF SE (DE) 2011-09-22 WO disclosed
WO-2011073145-A1 METHOD FOR PRODUCING TRIAZOLINTHIONE DERIVATIVES AND INTERMEDIATES THEREOF BASF SE (DE) 2011-06-23 WO disclosed