Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | AHR | P35869 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.50 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1202543 | 0.76 | IMPDH2 (0.63) | ATMGPR84MEN1CYP3A4KMT2A | |
| SCHEMBL2953261 | 0.74 | ATM (0.56) | ATMGPR84MEN1CYP3A4KMT2A | |
| SCHEMBL275615 | 0.72 | ATM (0.54) | ATMGPR84MEN1CYP3A4KMT2A | |
| SCHEMBL399039 | 0.72 | ATM (0.54) | ATMGPR84MEN1CYP3A4KMT2A | |
| SCHEMBL7495041 | 0.72 | ATM (0.54) | ATMGPR84MEN1CYP3A4KMT2A | |
| SCHEMBL4417668 | 0.72 | ATM (0.54) | ATMGPR84MEN1CYP3A4KMT2A | |
| SCHEMBL17376037 | 0.72 | ATM (0.54) | ATMGPR84MEN1CYP3A4KMT2A | |
| SCHEMBL9775725 | 0.72 | ATM (0.60) | ATMGPR84MEN1CYP3A4KMT2A | |
| SCHEMBL84022 | 0.72 | ATM (0.54) | ATMGPR84MEN1CYP3A4KMT2A | |
| SCHEMBL154499 | 0.72 | ATM (0.54) | ATMGPR84MEN1CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065908-B1 | ((ALKYL AND ALCENYL 3-PIPERIDYL-4(-2-ETHYL)-3 INDOLES, AND THEIR USE AS PHARMACEUTICAL PREPARATIONS | PHARMUKA LABORATOIRES (FR) | 1984-12-05 | — | — | EP | claimed |
| JP-5301873-A | — | — | None | — | — | JP | disclosed |
| JP-3261762-A | — | — | None | — | — | JP | disclosed |
| JP-5222037-A | — | — | None | — | — | JP | disclosed |
| CN-108383862-B | Indeno [2,1-b ] indolyl rare earth metal complex and preparation method thereof | 中国石油天然气股份有限公司 | 2021-03-30 | — | — | CN | disclosed |
| US-8884020-B2 | Indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20100197708-A1 | INDOLE COMPOUNDS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2010-08-05 | — | — | US | disclosed |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. | 2009-10-22 | — | — | US | disclosed |
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| US-20080090860-A1 | Retinoid x receptor modulators | GARDINIER KEVIN M | 2008-04-17 | — | — | US | disclosed |
| US-7348359-B2 | Retinoid X receptor modulators | ELI LILLY AND COMPANY (US) | 2008-03-25 | — | — | US | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |
| EP-1373240-B1 | RETINOID X RECEPTOR MODULATORS | LILLY CO ELI (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20040167160-A1 | Retinoid x receptor modulators | LIGAND PHARMACEUTICALS INCORPORATED | 2004-08-26 | — | — | US | disclosed |
| JP-H05301873-A | SULFONATED DIARYLETHENE DERIVATIVE | KANEBO LTD | 1993-11-16 | — | — | JP | disclosed |
| JP-H05222037-A | DIARYLETHENE DERIVATIVE | KANEBO LTD | 1993-08-31 | — | — | JP | disclosed |
| JP-H03261762-A | DIARYL ETHENE COMPOUND | KANEBO LTD | 1991-11-21 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167160-A1 | Retinoid x receptor modulators | RXRA, RXRG, RXRB | ATM 4784/4885GPR84 112/4885MEN1 4117/4885 |
| US-20080090860-A1 | Retinoid x receptor modulators | RXRA, RXRG, RXRB | ATM 4780/4885GPR84 112/4885MEN1 4261/4885 |
| US-20100197708-A1 | INDOLE COMPOUNDS | IDO1, IDO2, TPH2 | ATM 2656/4885GPR84 699/4885MEN1 3970/4885 |
| US-20090264653-A1 | USEFUL INDOLE COMPOUNDS | FAAH, FAAH2, AANAT | ATM 4768/4885GPR84 1246/4885MEN1 2374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.