Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013576 | 0.88 | METAP2 (0.42) | HTR1AKDM4ERAD52L3MBTL1ACHE | |
| SCHEMBL2018094 | 0.85 | HTR1A (0.43) | HTR1AKDM4ERAD52L3MBTL1ACHE | |
| SCHEMBL2013361 | 0.85 | METAP2 (0.43) | HTR1AKDM4ERAD52L3MBTL1ACHE | |
| SCHEMBL2014016 | 0.83 | MAPT (0.41) | KDM4ERAD52L3MBTL1HRH3ALDH1A1 | |
| SCHEMBL2017535 | 0.82 | MAPT (0.41) | HTR1AKDM4EL3MBTL1ALDH1A1HTR2A | |
| SCHEMBL2018360 | 0.80 | SLC40A1 (0.36) | KDM4EL3MBTL1ALDH1A1LMNAFFAR4 | |
| SCHEMBL2163161 | 0.78 | HTR1A (0.44) | HTR1AKDM4ERAD52L3MBTL1HRH3 | |
| SCHEMBL2164993 | 0.76 | HTR1A (0.44) | HTR1AKDM4EL3MBTL1HRH1HRH3 | |
| SCHEMBL2013917 | 0.74 | METAP2 (0.43) | KDM4EL3MBTL1ALDH1A1LMNANPSR1 | |
| SCHEMBL2015675 | 0.74 | METAP2 (0.43) | HTR1AKDM4ERAD52L3MBTL1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |