Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016552 | 0.86 | METAP2 (0.43) | MAPTSLC6A4HTR2AHTR2CKDM4E | |
| SCHEMBL2013524 | 0.82 | HTR1A (0.42) | HTR2AKDM4EALDH1A1HTR1AL3MBTL1 | |
| SCHEMBL2018360 | 0.81 | SLC40A1 (0.36) | MAPTKDM4EALDH1A1MPIL3MBTL1 | |
| SCHEMBL2164802 | 0.76 | L3MBTL1 (0.42) | MAPTPRKCQPRKCDSLC6A4HTR2A | |
| SCHEMBL2013917 | 0.74 | METAP2 (0.43) | MAPTKDM4EALDH1A1MPIL3MBTL1 | |
| SCHEMBL2015833 | 0.74 | KDM4E (0.53) | MAPTKDM4EALDH1A1HTR1ASLC6A2 | |
| SCHEMBL2017119 | 0.73 | METAP2 (0.42) | MAPTKDM4EALDH1A1MPIL3MBTL1 | |
| SCHEMBL2015083 | 0.71 | ALDH1A1 (0.54) | MAPTKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL2018198 | 0.70 | METAP2 (0.41) | MAPTKDM4EALDH1A1MPIL3MBTL1 | |
| SCHEMBL2014016 | 0.70 | MAPT (0.41) | MAPTKDM4EALDH1A1MPIL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |