Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.53 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140716 | 0.91 | MTOR (0.53) | MTORRPTORMLST8ALDH1A1DRD2 | |
| SCHEMBL20140044 | 0.91 | MTOR (0.54) | MTORRPTORMLST8ALDH1A1DRD2 | |
| SCHEMBL20156931 | 0.90 | MTOR (0.51) | MTORRPTORMLST8SMN1; SMN2ALDH1A1 | |
| SCHEMBL20141295 | 0.88 | KDM4E (0.50) | MTORRPTORMLST8SMN1; SMN2ALDH1A1 | |
| SCHEMBL20140587 | 0.87 | MTOR (0.54) | MTORRPTORMLST8SMN1; SMN2ALDH1A1 | |
| SCHEMBL20140585 | 0.85 | PPARG (0.47) | MTORRPTORMLST8DRD2DRD4 | |
| SCHEMBL20139909 | 0.83 | LMNA (0.52) | MTORRPTORMLST8SMN1; SMN2ALDH1A1 | |
| SCHEMBL20140693 | 0.83 | HCRTR1 (0.49) | MTORRPTORMLST8ALDH1A1HTT | |
| SCHEMBL20140664 | 0.83 | MTOR (0.57) | MTORRPTORMLST8ALDH1A1DRD2 | |
| SCHEMBL20140600 | 0.82 | KDM4E (0.54) | MTORRPTORMLST8ALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |