Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 3/20 | 0.34 |
| ▸ | GOT1 | P17174 | 2/20 | 0.33 |
| ▸ | RBP4 | P02753 | 2/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4558300 | 0.82 | SLC6A9 (0.44) | SLC6A7HTR6 | |
| SCHEMBL20141537 | 0.78 | KEAP1 (0.47) | KEAP1PDPK1BCHEGOT1 | |
| SCHEMBL6971671 | 0.77 | HTR2A (0.45) | SLC6A7 | |
| SCHEMBL20139744 | 0.77 | MAP4K4 (0.46) | BCHEIDO1 | |
| SCHEMBL30881604 | 0.77 | ADRA2C (0.45) | KEAP1SLC6A7RBP4NOTUM | |
| SCHEMBL17491559 | 0.77 | ADRA2C (0.45) | KEAP1SLC6A7RBP4NOTUM | |
| SCHEMBL4009517 | 0.76 | POLB (0.43) | SLC6A7 | |
| SCHEMBL2327343 | 0.76 | RBP4 (0.37) | SLC6A7HCRTR1RBP4NOTUM | |
| SCHEMBL2760636 | 0.75 | DRD2 (0.51) | — | |
| SCHEMBL29252729 | 0.75 | AGTR2 (0.48) | SLC6A7NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |