Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 8/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ME2 | P23368 | 1/20 | 0.34 |
| ▸ | ME1 | P48163 | 1/20 | 0.34 |
| ▸ | ME3 | Q16798 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20148197 | 0.82 | OPRM1 (0.49) | HRH3PARP1AOC3 | |
| SCHEMBL20148205 | 0.78 | HRH3 (0.46) | HRH3SIRT6PARP1EEDAOC3 | |
| SCHEMBL20148198 | 0.77 | HDAC3 (0.44) | HRH3PARP1AOC3HDAC3 | |
| SCHEMBL20148195 | 0.77 | KCNJ1 (0.39) | HRH3HPGDSMN1; SMN2ME2ME1 | |
| SCHEMBL5041190 | 0.77 | HRH3 (0.50) | HRH3SIRT6PARP1EEDAOC3 | |
| SCHEMBL29546455 | 0.75 | HRH3 (0.49) | HRH3SIRT6PARP1AOC3HPGD | |
| SCHEMBL20148203 | 0.73 | HRH3 (0.63) | HRH3SIRT6EED | |
| SCHEMBL29889648 | 0.73 | KMO (0.51) | HRH3SIRT6PARP1AOC3HPGD | |
| SCHEMBL5042063 | 0.73 | HDAC3 (0.51) | HRH3SIRT6HDAC3 | |
| SCHEMBL5040368 | 0.73 | KMO (0.51) | HRH3SIRT6PARP1AOC3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134688-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134688-A1 | NOVEL COMPOUNDS | RIPK2, RIPK1, RIPK4 | HRH3 3405/4885SIRT6 2014/4885PARP1 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.