Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.60 |
| ▸ | SPR | P35270 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2807714 | 0.85 | HSD11B1 (0.58) | HSD11B1SPRLMNANAMPTCYP2C9 | |
| SCHEMBL14413518 | 0.84 | HSD11B1 (0.56) | HSD11B1SPRLMNANAMPTCYP2C9 | |
| SCHEMBL14276847 | 0.84 | HSD11B1 (0.56) | HSD11B1SPRLMNANAMPTCYP2C9 | |
| SCHEMBL16600285 | 0.84 | HSD11B1 (0.56) | HSD11B1SPRLMNANAMPTCYP2C9 | |
| SCHEMBL20139653 | 0.83 | RAB9A (0.63) | HSD11B1SPRLMNACYP2C9NPC1 | |
| SCHEMBL17891160 | 0.83 | RAB9A (0.63) | HSD11B1SPRLMNACYP2C9NPC1 | |
| SCHEMBL20149062 | 0.82 | HSD11B1 (0.63) | HSD11B1SPRLMNANAMPTNPC1 | |
| SCHEMBL21740809 | 0.80 | HSD11B1 (0.53) | HSD11B1SPRLMNANAMPTCYP2C9 | |
| SCHEMBL17040329 | 0.80 | PDE4B (0.55) | HSD11B1SPRLMNANAMPTCYP2C9 | |
| SCHEMBL16565829 | 0.79 | RAB9A (0.67) | HSD11B1SPRLMNANAMPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078186-B2 | ROR γ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-08-03 | — | — | US | disclosed |
| WO-2018089406-A1 | ROR GAMMA MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078186-B2 | ROR γ modulators | RORB, RORC, RORA | HSD11B1 30/4885SPR 2412/4885LMNA 3884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.