Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20150512 | 0.91 | ALDH1A1 (0.45) | ALDH1A1NPSR1RECQLL3MBTL1NPBWR1 | |
| SCHEMBL20150565 | 0.90 | NPBWR1 (0.43) | ALDH1A1NPBWR1MCHR1KDM4EGAA | |
| SCHEMBL20150514 | 0.89 | PDE4B (0.43) | ALDH1A1NPSR1L3MBTL1PDE4BNPBWR1 | |
| SCHEMBL18285396 | 0.88 | KDM4E (0.49) | ALDH1A1NPSR1RECQLL3MBTL1PDE4B | |
| SCHEMBL1467162 | 0.86 | GABRA1 (0.48) | ALDH1A1PDE4BKDM4EGAALMNA | |
| SCHEMBL20150536 | 0.85 | L3MBTL1 (0.41) | ALDH1A1NPSR1RECQLL3MBTL1KDM4E | |
| SCHEMBL1467262 | 0.85 | PDE4B (0.46) | ALDH1A1PDE4BKDM4EPDGFRBLMNA | |
| SCHEMBL18293344 | 0.85 | ALDH1A1 (0.41) | ALDH1A1NPSR1RECQLL3MBTL1NPBWR1 | |
| SCHEMBL20150531 | 0.85 | ALDH1A1 (0.41) | ALDH1A1NPSR1RECQLL3MBTL1PDE4B | |
| SCHEMBL18285421 | 0.85 | NPSR1 (0.39) | ALDH1A1NPSR1RECQLL3MBTL1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134698-A1 | LIGANDS SELECTIVE TO ALPHA 6 SUBUNIT-CONTAINING GABAA RECEPTORS AND THEIR METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134698-A1 | LIGANDS SELECTIVE TO ALPHA 6 SUBUNIT-CONTAINING GABAA RECEPTORS AND THEIR METHODS OF USE | GABRA6, HTR6, GABRD | ALDH1A1 604/4885NPSR1 26/4885RECQL 2264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.