SCHEMBL20157485

SCHEMBL20157485

CCS(=O)(=O)Cc1ccc(C(=O)c2ccc(C)c(OC)c2)c(Br)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
ACHE P22303 5/20 0.39
CYP1A2 P05177 2/20 0.38
CYP2C19 P33261 2/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
TSHR P16473 1/20 0.38
PKM P14618 1/20 0.37
HPGD P15428 2/20 0.37
CYP2D6 P10635 1/20 0.37
PDF Q9HBH1 1/20 0.36
BCHE P06276 3/20 0.36
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
SLC22A6 Q4U2R8 1/20 0.36
SLC22A8 Q8TCC7 1/20 0.36
NPC1 O15118 1/20 0.36
MAPT P10636 2/20 0.36
KMT2A Q03164 1/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20158058 0.89 ALDH1A1 (0.41) ALDH1A1ACHECYP1A2CYP2C19CYP3A4
SCHEMBL20157679 0.88 ALDH1A1 (0.40) ALDH1A1ACHECYP1A2CYP2C19CYP3A4
SCHEMBL21557859 0.88 ALDH1A1 (0.40) ALDH1A1ACHECYP1A2CYP2C19CYP3A4
SCHEMBL21362793 0.87 PKM (0.49) ALDH1A1ACHECYP1A2CYP2C19CYP3A4
SCHEMBL21352105 0.85 ACHE (0.47) ALDH1A1ACHECYP1A2CYP2C19HPGD
SCHEMBL20157609 0.84 ALDH1A1 (0.46) ALDH1A1ACHECYP1A2CYP2C19CYP3A4
SCHEMBL20157411 0.83 NPC1 (0.48) ACHEPDFNPC1MAPTKMT2A
SCHEMBL20157342 0.82 SRD5A2 (0.43) ALDH1A1NPC1MAPTKMT2AGAA
SCHEMBL20158011 0.81 CA12 (0.38) ALDH1A1ACHECYP1A2CYP2C19HPGD
SCHEMBL20157726 0.80 ACHE (0.34) ALDH1A1ACHECYP1A2CYP2C19CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3539960-A1 NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) 2019-09-18 EP disclosed
WO-2018086605-A1 NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF 山东罗欣药业集团股份有限公司 2018-05-17 WO disclosed