Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22874060 | 0.75 | AURKA (0.43) | KDM4ELMNAAURKARPS6KB1SMN1; SMN2 | |
| SCHEMBL20161096 | 0.70 | STAT6 (0.47) | ALDH1A1KDM4ESMN1; SMN2MAPK1GAA | |
| SCHEMBL20161518 | 0.70 | CASP6 (0.43) | ALDH1A1KDM4ELMNAAURKARPS6KB1 | |
| SCHEMBL20161209 | 0.70 | AURKA (0.40) | ALDH1A1KDM4ELMNAAURKARPS6KB1 | |
| SCHEMBL19146434 | 0.70 | LMNA (0.35) | ALDH1A1KDM4ELMNAAURKARPS6KB1 | |
| SCHEMBL18359723 | 0.70 | SLC26A6 (0.36) | ALDH1A1KDM4ELMNAAURKARPS6KB1 | |
| SCHEMBL22213515 | 0.70 | LMNA (0.38) | ALDH1A1KDM4ELMNAAURKARPS6KB1 | |
| SCHEMBL19241027 | 0.70 | RPS6KB1 (0.37) | ALDH1A1KDM4ELMNAAURKARPS6KB1 | |
| SCHEMBL19240910 | 0.70 | AURKA (0.37) | ALDH1A1KDM4ELMNAAURKARPS6KB1 | |
| SCHEMBL20161113 | 0.69 | RPS6KB1 (0.41) | ALDH1A1KDM4ELMNAAURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |