Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20161518 | 0.83 | CASP6 (0.43) | RPS6KB1AURKALMNAKDM4EEGFR | |
| SCHEMBL20161209 | 0.82 | AURKA (0.40) | RPS6KB1AURKALMNAKDM4EMAPT | |
| SCHEMBL20149081 | 0.81 | KDM4E (0.38) | RPS6KB1AURKALMNAKDM4EGAA | |
| SCHEMBL20161268 | 0.80 | ACHE (0.36) | RPS6KB1AURKALMNAKDM4ECASP6 | |
| SCHEMBL20161291 | 0.80 | LMNA (0.39) | RPS6KB1AURKALMNAKDM4EGAA | |
| SCHEMBL20161118 | 0.77 | CSNK1D (0.46) | KDM4EMAPTGAAHTTALDH1A1 | |
| SCHEMBL20161301 | 0.77 | SMN1; SMN2 (0.55) | LMNAMEN1KMT2ANPC1HTT | |
| SCHEMBL20161340 | 0.77 | CYP11B1 (0.35) | RPS6KB1AURKALMNAKDM4EMAPT | |
| SCHEMBL20161335 | 0.74 | KDM4E (0.37) | RPS6KB1AURKALMNAKDM4EMAPT | |
| SCHEMBL22874060 | 0.72 | AURKA (0.43) | RPS6KB1AURKALMNAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |