Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.37 |
| ▸ | NQO2 | P16083 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170592 | 0.82 | MTNR1A (0.40) | MTNR1ANQO2MTNR1BHCRTR1KDM4E | |
| SCHEMBL20170607 | 0.82 | OPRM1 (0.37) | MTNR1ANQO2MTNR1BHCRTR1 | |
| SCHEMBL20170728 | 0.82 | OPRM1 (0.37) | MTNR1ANQO2MTNR1BHCRTR1 | |
| SCHEMBL20170652 | 0.82 | OPRM1 (0.37) | MTNR1ANQO2MTNR1BHCRTR1 | |
| SCHEMBL20170612 | 0.80 | ADRA1A (0.35) | DRD2 | |
| SCHEMBL20170605 | 0.80 | ADRA1A (0.35) | DRD2 | |
| SCHEMBL20170738 | 0.75 | HTR1A (0.40) | MTNR1ANQO2MTNR1BHCRTR1DRD2 | |
| SCHEMBL20170799 | 0.74 | HCRTR1 (0.47) | GABRA1GABRB2MTNR1ANQO2MTNR1B | |
| SCHEMBL20170645 | 0.73 | OPRM1 (0.39) | MTNR1ANQO2MTNR1BKDM4ELMNA | |
| SCHEMBL20170600 | 0.73 | OPRM1 (0.39) | MTNR1ANQO2MTNR1BKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |