Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 6/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170605 | 1.00 | ADRA1A (0.35) | ADRA1ADRD2DRD3HTR1A | |
| SCHEMBL20170607 | 0.85 | OPRM1 (0.37) | — | |
| SCHEMBL20170652 | 0.85 | OPRM1 (0.37) | — | |
| SCHEMBL20170728 | 0.85 | OPRM1 (0.37) | — | |
| SCHEMBL20170740 | 0.80 | — | — | |
| SCHEMBL20170753 | 0.80 | GABRA1 (0.39) | DRD2 | |
| SCHEMBL20170592 | 0.78 | MTNR1A (0.40) | — | |
| SCHEMBL20170738 | 0.77 | HTR1A (0.40) | DRD2DRD3HTR1A | |
| SCHEMBL20170641 | 0.76 | ADRA1A (0.34) | ADRA1AHTR1A | |
| SCHEMBL20170640 | 0.75 | HTR1A (0.34) | DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |