Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trimebutine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.74 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.66 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.66 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimebutine SCHEMBL1652810 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPTOPRM1OPRD1 | |
| Trimebutine SCHEMBL67225 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPTOPRM1OPRD1 | |
| Trimebutine SCHEMBL28274910 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPTOPRM1OPRD1 | |
| Trimebutine SCHEMBL5011979 | 0.86 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPTOPRM1OPRD1 | |
| Trimebutine SCHEMBL14273976 | 0.81 | OPRM1 (1.00) | ALDH1A1LMNAMAPTOPRM1OPRD1 | |
| Trimebutine SCHEMBL25705 | 0.81 | OPRM1 (1.00) | ALDH1A1LMNAMAPTOPRM1OPRD1 | |
| Trimebutine SCHEMBL7428847 | 0.80 | OPRM1 (0.98) | ALDH1A1LMNAMAPTOPRM1OPRD1 | |
| SCHEMBL16522145 | 0.76 | OPRM1 (0.88) | ALDH1A1LMNAMAPTOPRM1OPRD1 | |
| SCHEMBL14317655 | 0.74 | OPRM1 (0.83) | ALDH1A1LMNAMAPTOPRM1OPRD1 | |
| Maleic Acid SCHEMBL6116431 | 0.73 | KMT2A (0.68) | ALDH1A1LMNAMAPTOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152161-A1 | COMPOSITIONS FOR WEIGHT MANAGEMENT | MOR RESEARCH APPLICATIONS LTD. (IL) | 2010-06-17 | — | — | US | claimed |
| US-7737165-B2 | Methods of reducing weight gain associated with olanzapine treatment | MOR RESEARCH APPLICATIONS LTD. (IL) | 2010-06-15 | — | — | US | claimed |
| US-7728015-B2 | Compositions for weight management | MOR RESEARCH APPLICATIONS LTD. (IL) | 2010-06-01 | — | — | US | claimed |
| US-20080051440-A1 | Compositions for weight management | MOR RESEARCH APPLICATIONS LTD. (IL) | 2008-02-28 | — | — | US | claimed |
| US-20080051439-A1 | Methods of food intake management | MOR RESEARCH APPLICATIONS LTD. (IL) | 2008-02-28 | — | — | US | claimed |
| US-20080004324-A1 | Methods of preventing weight gain | MOR RESEARCH APPLICATIONS LTD. (IL) | 2008-01-03 | — | — | US | claimed |
| US-20080003306-A1 | Compositions for weight management | MOR RESEARCH APPLICATIONS LTD. (IL) | 2008-01-03 | — | — | US | claimed |
| US-20080004322-A1 | Methods of food intake management | MOR RESEARCH APPLICATIONS LTD. (IL) | 2008-01-03 | — | — | US | claimed |
| US-20080004254-A1 | Compositions for weight management | MOR RESEARCH APPLICATIONS LTD. (IL) | 2008-01-03 | — | — | US | claimed |
| EP-1737454-A4 | METHOD OF FOOD INTAKE MANAGEMENT | MOR RESEARCH APPLIC LTD (IL) | 2007-08-08 | — | — | EP | claimed |
| CN-1933835-A | Methods of preventing weight gain | MOR RESEARCH APPLIC LTD (IL) | 2007-03-21 | — | — | CN | claimed |
| EP-1737454-A2 | METHOD OF FOOD INTAKE MANAGEMENT | MOR RESEARCH APPLICATIONS LTD. (IL) | 2007-01-03 | — | — | EP | claimed |
| US-20060148787-A1 | Compositions for weight management | MOR RESEARCH APPLICATIONS LTD. | 2006-07-06 | — | — | US | claimed |
| US-20060084686-A1 | Methods of food intake management | MOR RESEARCH APPLICATIONS LTD. | 2006-04-20 | — | — | US | claimed |
| US-20060073217-A1 | Methods of preventing weight gain | MOR RESEARCH APPLICATIONS LTD. | 2006-04-06 | — | — | US | claimed |
| WO-2005101979-A2 | METHOD OF FOOD INTAKE MANAGEMENT | MOR RESEARCH APPLICATIONS LTD. (IL) | 2005-11-03 | — | — | WO | claimed |
| WO-2011073981-A2 | COMPOSITIONS AND METHODS FOR TREATING SOMNOLENCE | MOR RESEARCH APPLICATIONS LTD. (IL) | 2011-06-23 | — | — | WO | disclosed |
| US-20100152161-A1 | COMPOSITIONS FOR WEIGHT MANAGEMENT | MOR RESEARCH APPLICATIONS LTD. (IL) | 2010-06-17 | — | — | US | disclosed |
| US-20060073217-A1 | Methods of preventing weight gain | MOR RESEARCH APPLICATIONS LTD. | 2006-04-06 | — | — | US | disclosed |
| WO-2005101979-A2 | METHOD OF FOOD INTAKE MANAGEMENT | MOR RESEARCH APPLICATIONS LTD. (IL) | 2005-11-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004322-A1 | Methods of food intake management | HCRTR1, HCRTR2, HRH4 | HRH3 4/4885ALDH1A1 1759/4885LMNA 3046/4885 |
| US-20060148787-A1 | Compositions for weight management | HCRTR1, HCRTR2, GPR119 | HRH3 6/4885ALDH1A1 2341/4885LMNA 2417/4885 |
| US-20080003306-A1 | Compositions for weight management | HCRTR1, HCRTR2, GPR119 | HRH3 6/4885ALDH1A1 2341/4885LMNA 2417/4885 |
| US-20080004324-A1 | Methods of preventing weight gain | GPR119, HRH4, MTNR1A | HRH3 6/4885ALDH1A1 725/4885LMNA 1969/4885 |
| US-20080004254-A1 | Compositions for weight management | HCRTR1, HCRTR2, GPR119 | HRH3 6/4885ALDH1A1 2341/4885LMNA 2417/4885 |
| US-20060084686-A1 | Methods of food intake management | HCRTR1, HCRTR2, HRH4 | HRH3 4/4885ALDH1A1 1759/4885LMNA 3046/4885 |
| US-20100152161-A1 | COMPOSITIONS FOR WEIGHT MANAGEMENT | HNMT, BHMT, HRH4 | HRH3 4/4885ALDH1A1 1894/4885LMNA 1486/4885 |
| US-20060073217-A1 | Methods of preventing weight gain | GPR119, HRH4, MTNR1A | HRH3 6/4885ALDH1A1 725/4885LMNA 1969/4885 |
| US-20080051439-A1 | Methods of food intake management | HCRTR1, HCRTR2, HRH4 | HRH3 4/4885ALDH1A1 1759/4885LMNA 3046/4885 |
| US-20080051440-A1 | Compositions for weight management | HCRTR1, HCRTR2, GPR119 | HRH3 6/4885ALDH1A1 2260/4885LMNA 2454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.