SCHEMBL20177515

SCHEMBL20177515

COc1cc(F)c([C@H]2CC3Nc4ccccc4N3C2)c(F)c1

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.35
FPR2 P25090 5/20 0.34
FPR1 P21462 5/20 0.34
KDM1A O60341 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
CFTR P13569 1/20 0.33
CPS1 P31327 5/20 0.33
MEN1 O00255 1/20 0.32
GAA P10253 1/20 0.32
KMT2A Q03164 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPK1 P28482 1/20 0.32
BRD4 O60885 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20177564 0.84 KDM1A (0.32) KDM1A
SCHEMBL20177799 0.68 FPR2 (0.32) FPR2CPS1
SCHEMBL20177778 0.68 KDM4E (0.36) SMN1; SMN2KDM1AMAOBMEN1GAA
SCHEMBL20177481 0.68 FPR1 (0.31) FPR2FPR1CPS1
SCHEMBL20177834 0.64 PDE4A (0.44) SMN1; SMN2GAA
Acetic Acid SCHEMBL6476155 0.63 GAA (0.43) SMN1; SMN2MEN1GAAKMT2AALDH1A1
SCHEMBL20177560 0.61 ALDH1A1 (0.43) SMN1; SMN2MEN1GAAKMT2AALDH1A1
SCHEMBL22015871 0.60 FPR1 (0.36) FPR2FPR1
SCHEMBL18117730 0.59 PDE4A (0.60) SMN1; SMN2MEN1GAAKMT2AALDH1A1
SCHEMBL20177558 0.59 GRM2 (0.45) SMN1; SMN2FPR2FPR1GAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018092916-A1 NITROGEN-CONTAINING POLYCYCLIC HETEROCYCLIC DERIVATIVE 宇部興産株式会社 2018-05-24 WO disclosed