SCHEMBL20180539

SCHEMBL20180539

CC1(C)OB(c2cccc(Nc3c(C=N)ccc4ccccc34)c2)OC1(C)C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 0.42
LPL P06858 3/20 0.39
LIPG Q9Y5X9 3/20 0.39
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
KDM1A O60341 2/20 0.32
IRAK4 Q9NWZ3 1/20 0.32
POLB P06746 2/20 0.32
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
RAD52 P43351 1/20 0.32
GFER P55789 1/20 0.32
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GLA P06280 1/20 0.31
GAA P10253 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
ALPL P05186 1/20 0.31
FADS1 O60427 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20180320 0.87 EGFR (0.34) EGFR
SCHEMBL20180182 0.82 EGFR (0.40) EGFRLPLLIPGCA1CA2
SCHEMBL20180164 0.81 LPL (0.41) EGFRLPLLIPGCA1CA2
SCHEMBL20180132 0.79 EGFR (0.42) EGFRLPLLIPGCA1CA2
SCHEMBL20180540 0.77 TDO2 (0.46) EGFRKMT2AMEN1KDM4EALDH1A1
SCHEMBL3758531 0.73 LIPG (0.50) EGFRLPLLIPGCA1CA2
SCHEMBL20180311 0.73 LIPG (0.47) EGFRLPLLIPGCA1CA2
SCHEMBL20180141 0.73 LPL (0.37) EGFRLPLLIPGCA1CA2
SCHEMBL20180171 0.70 L3MBTL1 (0.41) KDM1APOLBKMT2AMEN1RAD52
SCHEMBL20180154 0.70 LIPG (0.41) EGFRLPLLIPGCA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018093107-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME 주식회사 두산 2018-05-24 WO disclosed