Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18201257 | 0.84 | ABCB1 (0.35) | ABCG2ABCB1 | |
| SCHEMBL20186463 | 0.81 | HTR6 (0.36) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL20186810 | 0.80 | AKR1B10 (0.33) | ALDH1A1ELANELMNA | |
| SCHEMBL20186695 | 0.73 | ABCB1 (0.38) | ABCG2ABCB1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL20186640 | 0.72 | NOD1 (0.36) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL20186802 | 0.71 | HSD17B10 (0.31) | ALDH1A1MEN1KMT2A | |
| SCHEMBL20186647 | 0.69 | HTR6 (0.37) | ALDH1A1TBXA2RPTGDRSMN1; SMN2KMT2A | |
| SCHEMBL20186692 | 0.68 | HSD11B1 (0.34) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20186744 | 0.67 | HTR2A (0.39) | ALDH1A1LMNA | |
| SCHEMBL5273285 | 0.61 | ALDH1A1 (0.57) | ABCG2ABCB1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288921-B1 | POLYCYCLIC INDOLINE AND INDOLENINE COMPOUNDS | UNIV COLORADO REGENTS (US) | 2022-06-15 | — | — | EP | disclosed |
| US-10253024-B2 | Polycyclic indoline and indolenine compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2019-04-09 | — | — | US | disclosed |
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10253024-B2 | Polycyclic indoline and indolenine compounds | IDO1, IDO2, INMT | ABCG2 1597/4885ABCB1 736/4885ALDH1A1 2671/4885 |
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | IDO1, IDO2, INMT | ABCG2 1597/4885ABCB1 736/4885ALDH1A1 2671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.