SCHEMBL20195488

SCHEMBL20195488

Cc1c(Cl)cccc1N(N)C(=O)NN

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.43
MAPT P10636 4/20 0.41
ALDH1A1 P00352 4/20 0.40
KDM4E B2RXH2 1/20 0.38
TSHR P16473 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
HPGD P15428 2/20 0.38
USP2 O75604 1/20 0.38
MT-CO2 P00403 1/20 0.38
TTR P02766 1/20 0.38
PLA2G1B P04054 1/20 0.38
CYP1A2 P05177 1/20 0.38
PGR P06401 1/20 0.38
CYP3A4 P08684 1/20 0.38
HTR1A P08908 1/20 0.38
ADRA2A P08913 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
AR P10275 1/20 0.38
CYP2C9 P11712 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19909862 0.83 ALDH1A1 (0.39) LMNAMAPTALDH1A1TSHRMEN1
SCHEMBL27669364 0.83 POLB (0.37) LMNAMAPTALDH1A1KDM4EMEN1
SCHEMBL22563901 0.81 OGG1 (0.34) LMNAMAPTALDH1A1KDM4ETSHR
SCHEMBL20686606 0.81 HSD17B1 (0.38) MAPTALDH1A1MEN1KMT2ASMN1; SMN2
SCHEMBL19904127 0.81 ALDH1A1 (0.33) LMNAMAPTALDH1A1KDM4EMEN1
SCHEMBL18030820 0.79 ALDH1A1 (0.40) LMNAMAPTALDH1A1KDM4ETSHR
SCHEMBL18831312 0.78 CTSD (0.44) LMNAMAPTALDH1A1KDM4ETSHR
SCHEMBL20342849 0.77 TAS2R14 (0.42) LMNAMAPTALDH1A1HPGDPOLB
SCHEMBL27758851 0.77 TTR (0.38) TTRCYP1A2HDAC4
SCHEMBL19006796 0.76 TP53 (0.39) LMNAMAPTALDH1A1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3020715-B1 TETRAZOLINONE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL CO (JP) 2021-06-16 EP disclosed
EP-2841429-B1 TETRAZOLINONE COMPOUNDS AND ITS USE AS PESTICIDES SUMITOMO CHEMICAL CO (JP) 2020-10-21 EP disclosed
EP-2940012-B1 TETRAZOLINONE COMPOUND AND APPLICATIONS THEREOF SUMITOMO CHEMICAL CO (JP) 2019-01-30 EP disclosed
EP-3029035-B1 TETRAZOLINONE COMPOUND, AND USE THEREOF SUMITOMO CHEMICAL CO (JP) 2018-05-30 EP disclosed