Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18282344 | 0.98 | RIPK1 (0.42) | RIPK1MTNR1AMTNR1BBCHEKDM4E | |
| SCHEMBL23330971 | 0.92 | LMNA (0.39) | RIPK1BCHEKDM4EKMT2AALDH1A1 | |
| SCHEMBL8594851 | 0.89 | SIGMAR1 (0.40) | RIPK1MTNR1AMTNR1BBCHEKDM4E | |
| Hydrochloric Acid SCHEMBL8599844 | 0.88 | SIGMAR1 (0.39) | RIPK1MTNR1AMTNR1BBCHEKDM4E | |
| SCHEMBL16377844 | 0.83 | KMT2A (0.48) | RIPK1MTNR1AMTNR1BBCHEKDM4E | |
| SCHEMBL12640147 | 0.82 | CES2 (0.41) | RIPK1MTNR1AMTNR1BBCHEKDM4E | |
| SCHEMBL22626227 | 0.81 | RIPK1 (0.40) | RIPK1MTNR1AMTNR1BBCHEKDM4E | |
| SCHEMBL12824157 | 0.81 | SIGMAR1 (0.46) | RIPK1MTNR1AMTNR1BBCHEKDM4E | |
| SCHEMBL24134198 | 0.80 | RIPK1 (0.37) | RIPK1MTNR1AMTNR1BKDM4EKMT2A | |
| SCHEMBL17789636 | 0.79 | RIPK1 (0.41) | RIPK1MTNR1AMTNR1BBCHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230338376-A1 | AMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2023-10-26 | — | — | US | disclosed |
| US-20230338376-A1 | AMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2023-10-26 | — | — | US | disclosed |
| US-11590134-B2 | Aminopyrimidine amide autophagy inhibitors and methods of use thereof | DECIPHERA PHARMACEUTICALS, LLC (US) | 2023-02-28 | — | — | US | disclosed |
| US-20210145832-A1 | TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2021-05-20 | — | — | US | disclosed |
| US-20210128556-A1 | AMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2021-05-06 | — | — | US | disclosed |
| US-10946017-B2 | Tank-binding kinase-1 PROTACs and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2021-03-16 | — | — | US | disclosed |
| WO-2020257180-A1 | AMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2020-12-24 | — | — | WO | disclosed |
| US-20190192514-A1 | TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE | Arvinas, Inc. | 2019-06-27 | — | — | US | disclosed |
| US-20180147202-A1 | TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180147202-A1 | TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE | TBK1, TBKBP1, TNKS | RIPK1 9/4885MTNR1A 4096/4885MTNR1B 4355/4885 |
| US-20210145832-A1 | TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE | TBK1, TNKS, TBKBP1 | RIPK1 9/4885MTNR1A 3792/4885MTNR1B 4103/4885 |
| US-20210128556-A1 | AMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | BECN1, SQSTM1, ATG7 | RIPK1 935/4885MTNR1A 3276/4885MTNR1B 3191/4885 |
| US-11590134-B2 | Aminopyrimidine amide autophagy inhibitors and methods of use thereof | BECN1, SQSTM1, ATG7 | RIPK1 935/4885MTNR1A 3276/4885MTNR1B 3191/4885 |
| US-10946017-B2 | Tank-binding kinase-1 PROTACs and associated methods of use | TBK1, TNKS, TBKBP1 | RIPK1 9/4885MTNR1A 3792/4885MTNR1B 4103/4885 |
| US-20230338376-A1 | AMINOPYRIMIDINE AMIDE AUTOPHAGY INHIBITORS AND METHODS OF USE THEREOF | BECN1, SQSTM1, ATG7 | RIPK1 935/4885MTNR1A 3276/4885MTNR1B 3191/4885 |
| US-20190192514-A1 | TANK-BINDING KINASE-1 PROTACs AND ASSOCIATED METHODS OF USE | TBK1, TNKS, TBKBP1 | RIPK1 9/4885MTNR1A 3792/4885MTNR1B 4103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.