Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MARK3 | P27448 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20202029 | 0.80 | RIPK1 (0.33) | BRD4MAPK1PARP15PARP10CHUK | |
| SCHEMBL20207783 | 0.80 | ALOX5AP (0.32) | BRD4PARP15PARP10CHUKALOX5AP | |
| SCHEMBL20207074 | 0.68 | PARP10 (0.45) | PARP15PARP10 | |
| SCHEMBL20376461 | 0.66 | CYP1A2 (0.38) | BRD4ALOX5APFEN1 | |
| SCHEMBL21325059 | 0.66 | PDE3B (0.35) | PARP15PARP10CHUKALOX5APFEN1 | |
| SCHEMBL29037151 | 0.64 | AXL (0.36) | PARP15PARP10ALOX5APFEN1 | |
| SCHEMBL21690528 | 0.64 | RIPK1 (0.38) | PARP15PARP10ALOX5APFEN1 | |
| SCHEMBL20204677 | 0.64 | PDE2A (0.37) | PARP15PARP10CHUKALOX5APFEN1 | |
| SCHEMBL20202028 | 0.64 | PIK3R1 (0.39) | KDRALOX5APFEN1 | |
| SCHEMBL21325057 | 0.63 | RIPK1 (0.37) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098209-A1 | AMINO SULFONYL COMPOUNDS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |