Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 12/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 11/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472288 | 0.87 | TLR8 (0.38) | TLR8TLR7CYP3A4L3MBTL1CRHR1 | |
| SCHEMBL13195066 | 0.86 | L3MBTL1 (0.48) | TLR8TLR7L3MBTL1 | |
| SCHEMBL13195124 | 0.80 | L3MBTL1 (0.49) | TLR8TLR7L3MBTL1 | |
| SCHEMBL23472526 | 0.79 | TLR8 (0.47) | TLR8TLR7CYP3A4L3MBTL1TSHR | |
| SCHEMBL23472109 | 0.79 | TLR8 (0.38) | TLR8TLR7CYP3A4L3MBTL1TSHR | |
| SCHEMBL23472323 | 0.77 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL20219572 | 0.77 | CYP2D6 (0.43) | TLR8TLR7CYP3A4TSHR | |
| SCHEMBL20219723 | 0.77 | ALDH1A1 (0.38) | TLR8TLR7CRHR1 | |
| SCHEMBL20219396 | 0.77 | TLR8 (0.35) | TLR8TLR7CYP3A4L3MBTL1CRHR1 | |
| SCHEMBL20219386 | 0.76 | SCN9A (0.36) | TLR8TLR7CYP3A4L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |