Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 5/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15470035 | 0.89 | TLR7 (0.43) | TLR7TLR8CYP1A2CYP3A4L3MBTL1 | |
| SCHEMBL20219471 | 0.81 | NPSR1 (0.44) | TLR7TLR8CYP1A2CYP3A4KDM4E | |
| SCHEMBL20219347 | 0.78 | HTR1A (0.50) | TLR8KDRMET | |
| SCHEMBL23472288 | 0.77 | TLR8 (0.38) | TLR7TLR8CYP3A4KDM4ENPSR1 | |
| SCHEMBL20219572 | 0.77 | CYP2D6 (0.43) | TLR7NPC1TLR8CYP1A2CYP3A4 | |
| SCHEMBL20219324 | 0.74 | CHRNB2 (0.47) | TLR7TLR8CYP1A2CYP3A4 | |
| SCHEMBL23472526 | 0.74 | TLR8 (0.47) | TLR7PDE4BPDE4DPDE3ATLR8 | |
| SCHEMBL23472109 | 0.74 | TLR8 (0.38) | TLR7NPC1TLR8CYP3A4KDM4E | |
| SCHEMBL23472518 | 0.73 | TLR7 (0.45) | TLR7TLR8CYP1A2CYP3A4LATS1 | |
| SCHEMBL20219723 | 0.72 | ALDH1A1 (0.38) | TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590928-B1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2021-06-09 | — | — | EP | disclosed |
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |