Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MYOC | Q99972 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SCN4A | P35499 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2240147 | 0.89 | SCN2A (0.56) | ALDH1A1MEN1KMT2AMAPTSCN2A | |
| SCHEMBL7123299 | 0.84 | SCN2A (0.51) | ALDH1A1MAPTMAPK1SCN2ALMNA | |
| SCHEMBL11689190 | 0.81 | HSPB1 (0.79) | HSPB1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2011179 | 0.81 | HSPB1 (0.79) | HSPB1ALDH1A1MEN1KMT2AMAPT | |
| 4,4'-Oxybis(Nitrobenzene) SCHEMBL134332 | 0.81 | HSPB1 (0.79) | HSPB1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9183872 | 0.81 | HSPB1 (0.79) | HSPB1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL328169 | 0.80 | HSPB1 (0.49) | HSPB1ALDH1A1MEN1KMT2AMAPT | |
| 4,4'-Oxybis(Nitrobenzene) SCHEMBL8934595 | 0.79 | HSPB1 (0.76) | HSPB1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL457863 | 0.77 | HSPB1 (0.68) | HSPB1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7013183 | 0.75 | LTA4H (0.55) | MEN1KMT2ANPSR1KDM4ELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551608-A1 | PENDANT AMINES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | Celtaxsys Inc. (US) | 2019-10-16 | — | — | EP | disclosed |
| US-20190161437-A1 | PENDANT AMINES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | CELTAXSYS INC (US) | 2019-05-30 | — | — | US | disclosed |
| US-10202334-B2 | Pendant amines and derivatives as inhibitors of leukotriene A4 hydrolase | CELTAXSYS, INC. (US) | 2019-02-12 | — | — | US | disclosed |
| WO-2018107167-A1 | PENDANT AMINES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | CELTAXSYS, INC. (US) | 2018-06-14 | — | — | WO | disclosed |
| US-20180162804-A1 | PENDANT AMINES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | CELLTAXIS, LLC | 2018-06-14 | — | — | US | disclosed |
| US-20180162804-A1 | PENDANT AMINES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | CELLTAXIS, LLC | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162804-A1 | PENDANT AMINES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | LTA4H, LTB4R, LTC4S | HSPB1 3621/4885ALDH1A1 511/4885MEN1 2536/4885 |
| US-10202334-B2 | Pendant amines and derivatives as inhibitors of leukotriene A4 hydrolase | LTA4H, LTB4R, LTC4S | HSPB1 3621/4885ALDH1A1 511/4885MEN1 2536/4885 |
| US-20190161437-A1 | PENDANT AMINES AND DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | LTA4H, LTC4S, LTB4R | HSPB1 3467/4885ALDH1A1 537/4885MEN1 2692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.