Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PLAAT3 | P53816 | 3/20 | 0.45 |
| ▸ | PLAAT5 | Q96KN8 | 3/20 | 0.45 |
| ▸ | PLAAT2 | Q9NWW9 | 3/20 | 0.45 |
| ▸ | PLAAT4 | Q9UL19 | 3/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239168 | 0.86 | RAB9A (0.47) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20259077 | 0.85 | ALDH1A1 (0.62) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20239189 | 0.85 | RAB9A (0.46) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20239165 | 0.81 | DGAT2 (0.47) | ALDH1A1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL20239326 | 0.81 | ALDH1A1 (0.43) | ALDH1A1RAB9ASMN1; SMN2KMT2APLAAT3 | |
| SCHEMBL5338527 | 0.78 | OPRM1 (0.54) | PLAAT3PLAAT5PLAAT2PLAAT4EPHX2 | |
| SCHEMBL20239173 | 0.77 | SMN1; SMN2 (0.46) | ALDH1A1RAB9ASMN1; SMN2NPC1PLAAT3 | |
| SCHEMBL20239158 | 0.76 | EPHX2 (0.43) | ALDH1A1RAB9ASMN1; SMN2KMT2APLAAT3 | |
| SCHEMBL2773493 | 0.76 | EPHX2 (0.70) | ALDH1A1RAB9ASMN1; SMN2NPC1PLAAT3 | |
| SCHEMBL21332641 | 0.75 | EPHX2 (0.58) | ALDH1A1SMN1; SMN2PLAAT3PLAAT5PLAAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298001-B1 | DGAT2 INHIBITORS | LILLY CO ELI (US) | 2020-05-13 | — | — | EP | disclosed |
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | ALDH1A1 1430/4885RAB9A 1170/4885SMN1; SMN2 4828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.