Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.54 |
| ▸ | PLAAT3 | P53816 | 6/20 | 0.47 |
| ▸ | PLAAT5 | Q96KN8 | 6/20 | 0.47 |
| ▸ | PLAAT2 | Q9NWW9 | 6/20 | 0.47 |
| ▸ | PLAAT4 | Q9UL19 | 6/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.45 |
| ▸ | LTA4H | P09960 | 4/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239237 | 0.78 | ALDH1A1 (0.65) | OPRM1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL902861 | 0.77 | NOS1 (0.53) | — | |
| SCHEMBL30941666 | 0.77 | EPHX2 (0.69) | OPRM1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL23582337 | 0.76 | CYP4F2 (0.44) | OPRM1F2F10PRSS1PRSS2 | |
| SCHEMBL20239168 | 0.76 | RAB9A (0.47) | OPRM1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL20239189 | 0.75 | RAB9A (0.46) | OPRM1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL20239174 | 0.74 | LOXL2 (0.53) | OPRM1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL6223063 | 0.73 | OPRM1 (0.74) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL20239158 | 0.73 | EPHX2 (0.43) | OPRM1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL6630918 | 0.73 | F2 (0.42) | OPRM1F2F10PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1309589-B1 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC (US) | 2006-03-15 | — | — | EP | disclosed |
| EP-1619184-A2 | Urea compounds as kinase inhibitors | Amgen, Inc. (US) | 2006-01-25 | — | — | EP | disclosed |
| US-20040044044-A1 | Thiazolyl urea compounds and methods of uses | AMGEN INC. | 2004-03-04 | — | — | US | disclosed |
| US-20040039029-A1 | Thiazolyl urea compounds and methods of uses | AMGEN INC. | 2004-02-26 | — | — | US | disclosed |
| US-6645990-B2 | For prophylaxis and therapy of diseases, such as cell proliferation or apoptosis mediated diseases | AMGEN INC. | 2003-11-11 | — | — | US | disclosed |
| US-20020193405-A1 | Thiazolyl urea compounds and methods of uses | AMGEN INC. | 2002-12-19 | — | — | US | disclosed |
| US-20020173507-A1 | Urea compounds and methods of uses | AMGEN INC. | 2002-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193405-A1 | Thiazolyl urea compounds and methods of uses | SLC14A1, UMPS, BAX | OPRM1 3812/4885PLAAT3 3037/4885PLAAT5 2428/4885 |
| US-20020173507-A1 | Urea compounds and methods of uses | SLC14A1, UMPS, BAX | OPRM1 3040/4885PLAAT3 3067/4885PLAAT5 2398/4885 |
| US-20040039029-A1 | Thiazolyl urea compounds and methods of uses | SLC14A1, UMPS, BAX | OPRM1 3812/4885PLAAT3 3037/4885PLAAT5 2428/4885 |
| US-20040044044-A1 | Thiazolyl urea compounds and methods of uses | SLC14A1, UMPS, BAX | OPRM1 3812/4885PLAAT3 3037/4885PLAAT5 2428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.