Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | PLAAT3 | P53816 | 4/20 | 0.39 |
| ▸ | PLAAT5 | Q96KN8 | 4/20 | 0.39 |
| ▸ | PLAAT2 | Q9NWW9 | 4/20 | 0.39 |
| ▸ | PLAAT4 | Q9UL19 | 4/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 2/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239168 | 0.88 | RAB9A (0.47) | EPHX2OPRM1ACACBPLAAT3PLAAT5 | |
| SCHEMBL20259223 | 0.87 | CA2 (0.43) | ALDH1A1RAB9AGLAKMT2A | |
| SCHEMBL20239174 | 0.82 | LOXL2 (0.53) | EPHX2OPRM1ACACBPLAAT3PLAAT5 | |
| SCHEMBL20239138 | 0.81 | EPHX2 (0.43) | EPHX2OPRM1ACACBPLAAT3PLAAT5 | |
| SCHEMBL20239244 | 0.80 | DGAT2 (0.48) | EPHX2OPRM1ACACBPLAAT3PLAAT5 | |
| SCHEMBL20239192 | 0.80 | OPRM1 (0.40) | EPHX2OPRM1ACACBPLAAT3PLAAT5 | |
| SCHEMBL16747531 | 0.77 | SMN1; SMN2 (0.43) | ALDH1A1RAB9ASMN1; SMN2KMT2ALOX | |
| SCHEMBL20259240 | 0.76 | RAB9A (0.47) | ALDH1A1RAB9ASMN1; SMN2GLAKMT2A | |
| SCHEMBL18249764 | 0.76 | LOXL2 (0.65) | LOXLOXL2 | |
| SCHEMBL20239237 | 0.76 | ALDH1A1 (0.65) | EPHX2OPRM1PLAAT3PLAAT5PLAAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298001-B1 | DGAT2 INHIBITORS | LILLY CO ELI (US) | 2020-05-13 | — | — | EP | disclosed |
| US-10053429-B2 | DGAT2 inhibitors | ELI LILLY AND COMPANY (US) | 2018-08-21 | — | — | US | disclosed |
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | ELI LILY AND COMPANY (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162825-A1 | NOVEL DGAT2 INHIBITORS | DGAT2, DGAT1, LCAT | EPHX2 1522/4885OPRM1 4494/4885ACACB 152/4885 |
| US-10053429-B2 | DGAT2 inhibitors | DGAT2, DGAT1, LCAT | EPHX2 1200/4885OPRM1 4206/4885ACACB 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.