Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 9/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8663801 | 0.82 | HDAC1 (0.49) | MAPTKDM4ERAB9AALDH1A1DGAT1 | |
| SCHEMBL17595785 | 0.80 | ALDH1A1 (0.43) | NPSR1HCAR3HCAR2MAPTKDM4E | |
| SCHEMBL8662091 | 0.78 | DGAT1 (0.60) | MAPTKDM4ERAB9ANPC1ALDH1A1 | |
| SCHEMBL5059081 | 0.77 | MAPT (0.55) | NPSR1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL5643285 | 0.72 | ALDH1A1 (0.47) | MAPTALDH1A1 | |
| SCHEMBL5086187 | 0.72 | ALDH1A1 (0.50) | MAPTRAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL27929947 | 0.72 | HCAR2 (0.46) | HCAR2MAPTKDM4EALDH1A1GAA | |
| SCHEMBL10878020 | 0.71 | PARP10 (0.56) | NPSR1MAPTKDM4ERAB9ANPC1 | |
| SCHEMBL6783785 | 0.71 | L3MBTL1 (0.52) | HCAR3HCAR2MAPTKDM4EALDH1A1 | |
| SCHEMBL29640466 | 0.71 | L3MBTL1 (0.52) | HCAR3HCAR2MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018106818-A1 | METHODS OF PROMOTING BETA CELL PROLIFERATION | KURA ONCOLOGY, INC. (US) | 2018-06-14 | — | — | WO | disclosed |