SCHEMBL20264995

SCHEMBL20264995

O=C1COc2c(Cl)c[c]cc2N1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IL4I1 Q96RQ9 1/20 0.39
NR3C1 P04150 2/20 0.38
PGR P06401 2/20 0.38
NR3C2 P08235 2/20 0.38
MMP12 P39900 1/20 0.36
MAPT P10636 4/20 0.33
ALDH1A1 P00352 2/20 0.33
PDE3B Q13370 2/20 0.33
PDE3A Q14432 2/20 0.33
MALT1 Q9UDY8 1/20 0.33
PARP1 P09874 1/20 0.33
AR P10275 1/20 0.33
DRD2 P14416 1/20 0.32
DRD4 P21917 1/20 0.32
DRD3 P35462 1/20 0.32
KMT2A Q03164 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
PKM P14618 2/20 0.32
MEN1 O00255 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL910457 0.79 NR3C2 (0.38) NR3C1PGRNR3C2MMP12ALDH1A1
SCHEMBL31170719 0.74 IL4I1 (0.45) IL4I1NR3C1PGRNR3C2MMP12
SCHEMBL20278370 0.72 PDE3B (0.55) IL4I1NR3C1PGRNR3C2MMP12
SCHEMBL8236302 0.72 IL4I1 (0.44) IL4I1NR3C1PGRNR3C2MMP12
SCHEMBL3600619 0.72 IL4I1 (0.44) IL4I1NR3C1PGRNR3C2MMP12
SCHEMBL4290482 0.72 IL4I1 (0.44) IL4I1NR3C1PGRNR3C2MMP12
SCHEMBL31170800 0.70 CES1 (0.41) IL4I1NR3C1PGRNR3C2MMP12
SCHEMBL5340556 0.70 IL4I1 (0.43) IL4I1NR3C1PGRNR3C2MMP12
SCHEMBL24869557 0.69 NR3C1 (0.43) IL4I1NR3C1PGRNR3C2MMP12
SCHEMBL8489457 0.69 NR3C2 (0.44) IL4I1NR3C1PGRNR3C2MMP12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230310413-A1 PHARMACEUTICAL FORMULATIONS COMPRISING A MALT1 INHIBITOR AND A MIXTURE OF POLYETHYLENE GLYCOL WITH A FATTY ACID JANSSEN PHARMACEUTICA NV (BE) 2023-10-05 US claimed
CN-115884773-A Pharmaceutical preparation 詹森药业有限公司 2023-03-31 CN claimed
CN-115210567-A Methods of assessing efficacy of MALT1 inhibitors using NF-KB translocation assays 詹森药业有限公司 2022-10-18 CN claimed
CN-114981453-A NF-KB regulated gene expression assay for assessing efficacy of MALT1 inhibitors 詹森药业有限公司 2022-08-30 CN claimed
US-20220175760-A1 PHARMACEUTICAL FORMULATIONS JANSSEN PHARMACEUTICA NV (BE) 2022-06-09 US claimed
US-20210155990-A1 NF-KB REGULATED GENE EXPRESSION ASSAY FOR ASSESSING EFFICACY OF MALT1 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 US claimed
US-20210156865-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 US claimed
US-20180170909-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS JANSSEN-CILAG (FR) 2018-06-21 US claimed
CN-113473971-B Pharmaceutical formulations 詹森药业有限公司 2024-07-02 CN disclosed
US-20230414629-A1 MATERIALS AND METHODS OF TREATING CANCER MONOPTEROS THERAPEUTICS, INC. 2023-12-28 US disclosed
US-20230310413-A1 PHARMACEUTICAL FORMULATIONS COMPRISING A MALT1 INHIBITOR AND A MIXTURE OF POLYETHYLENE GLYCOL WITH A FATTY ACID JANSSEN PHARMACEUTICA NV (BE) 2023-10-05 US disclosed
EP-4243812-A1 MATERIALS AND METHODS OF TREATING CANCER Monopteros Therapeutics, Inc. (US) 2023-09-20 EP disclosed
US-20230235077-A1 MATERIALS AND METHODS OF TREATING CANCER THE GENERAL HOSPITAL CORPORATION (US) 2023-07-27 US disclosed
CN-115884773-A Pharmaceutical preparation 詹森药业有限公司 2023-03-31 CN disclosed
US-20210155990-A1 NF-KB REGULATED GENE EXPRESSION ASSAY FOR ASSESSING EFFICACY OF MALT1 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 US disclosed
US-10954214-B2 Pyrazole derivatives as MALT1 inhibitors JANSSEN PHARMACEUTICA NV (BE) 2021-03-23 US disclosed
US-20210052596-A1 TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS TO INFLAME THE TUMOR MICROENVIRONMENT THE GENERAL HOSPITAL CORPORATION (US) 2021-02-25 US disclosed
EP-3731848-A1 TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS TO INFLAME THE TUMOR MICROENVIRONMENT The General Hospital Corporation (US) 2020-11-04 EP disclosed
CN-111770759-A Targeting the CBM-signalosome complex to induce regulatory T cells to inflame the tumor microenvironment 通用医疗公司 2020-10-13 CN disclosed
US-20180170909-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS JANSSEN-CILAG (FR) 2018-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10954214-B2 Pyrazole derivatives as MALT1 inhibitors MALT1, PPP3R1, SQSTM1 IL4I1 1519/4885NR3C1 586/4885PGR 2789/4885
US-20210052596-A1 TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS TO INFLAME THE TUMOR MICROENVIRONMENT CD47, ICOS, LCK IL4I1 2165/4885NR3C1 1575/4885PGR 3296/4885
US-20210155990-A1 NF-KB REGULATED GENE EXPRESSION ASSAY FOR ASSESSING EFFICACY OF MALT1 INHIBITORS MALT1, NFKBIA, NFKB2 IL4I1 783/4885NR3C1 316/4885PGR 4571/4885
US-20230235077-A1 MATERIALS AND METHODS OF TREATING CANCER MALT1, CD274, TP53 IL4I1 2913/4885NR3C1 2310/4885PGR 3340/4885
US-20230310413-A1 PHARMACEUTICAL FORMULATIONS COMPRISING A MALT1 INHIBITOR AND A MIXTURE OF POLYETHYLENE GLYCOL WITH A FATTY ACID MALT1, MGAM, MGLL IL4I1 2608/4885NR3C1 459/4885PGR 3282/4885
US-20220175760-A1 PHARMACEUTICAL FORMULATIONS TREH, F12, CEL IL4I1 3455/4885NR3C1 3233/4885PGR 1736/4885
US-20180170909-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS MALT1, PPP3R1, SQSTM1 IL4I1 1519/4885NR3C1 586/4885PGR 2789/4885
US-20230414629-A1 MATERIALS AND METHODS OF TREATING CANCER MALT1, TP53, RAD1 IL4I1 3202/4885NR3C1 2238/4885PGR 3710/4885
US-20210156865-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY NFKBIA, MALT1, NFATC1 IL4I1 1438/4885NR3C1 352/4885PGR 4690/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.