Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 3/20 | 0.49 |
| ▸ | HTR1A known ✓ | P08908 | 6/20 | 0.45 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2032504 | 0.98 | SIGMAR1 (0.50) | SIGMAR1HTR1APRCPMAOBMAOA | |
| SCHEMBL3894893 | 0.80 | SIGMAR1 (0.50) | SIGMAR1HTR1APRCPMAOBMAOA | |
| SCHEMBL3894933 | 0.80 | SIGMAR1 (0.50) | SIGMAR1HTR1APRCPMAOBMAOA | |
| SCHEMBL8099494 | 0.80 | SIGMAR1 (0.50) | SIGMAR1HTR1APRCPMAOBMAOA | |
| SCHEMBL8099489 | 0.80 | SIGMAR1 (0.50) | SIGMAR1HTR1APRCPMAOBMAOA | |
| SCHEMBL7538877 | 0.76 | SIGMAR1 (0.55) | SIGMAR1HTR1APRCPMAOBMAOA | |
| SCHEMBL9277494 | 0.70 | SIGMAR1 (0.41) | SIGMAR1HTR1APRCPMAOBMAOA | |
| SCHEMBL8395590 | 0.70 | SIGMAR1 (0.59) | SIGMAR1HTR1AMAOBMAOAGRIN2B | |
| Bromide SCHEMBL2033463 | 0.69 | SIGMAR1 (0.42) | SIGMAR1HTR1A | |
| SCHEMBL7130225 | 0.68 | GRIN2D (0.42) | SIGMAR1OPRM1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741962-B2 | Process for preparation of Rasagiline and salts thereof | USV LIMITED (IN) | 2014-06-03 | — | — | US | claimed |
| EP-2364967-A2 | Process for preparation of rasagiline and salts thereof | USV Limited (IN) | 2011-09-14 | — | — | EP | claimed |
| US-20110155626-A1 | PROCESS FOR PREPARATION OF RASAGILINE AND SALTS THEREOF | USV LIMITED (IN) | 2011-06-30 | — | — | US | claimed |
| US-8741962-B2 | Process for preparation of Rasagiline and salts thereof | USV LIMITED (IN) | 2014-06-03 | — | — | US | disclosed |
| EP-2364967-A2 | Process for preparation of rasagiline and salts thereof | USV Limited (IN) | 2011-09-14 | — | — | EP | disclosed |
| US-20110155626-A1 | PROCESS FOR PREPARATION OF RASAGILINE AND SALTS THEREOF | USV LIMITED (IN) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110155626-A1 | PROCESS FOR PREPARATION OF RASAGILINE AND SALTS THEREOF | RAB27A, RAB35, RAB7A | SIGMAR1 3861/4885HTR1A 1838/4885GRIN2A 4126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.