Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20350809 | 0.90 | KDM4E (0.55) | KDM4EALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL26847300 | 0.89 | LMNA (0.58) | KDM4EALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL24088076 | 0.89 | LMNA (0.55) | KDM4EALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL20350883 | 0.85 | ALDH1A1 (0.47) | KDM4EALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL23849883 | 0.84 | ACMSD (0.48) | KDM4EALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL24087892 | 0.84 | LMNA (0.53) | KDM4EALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL20340043 | 0.83 | KDM4E (0.64) | KDM4EALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL20351084 | 0.82 | ALDH1A1 (0.45) | KDM4EALDH1A1KMT2AHPGDLMNA | |
| SCHEMBL20340101 | 0.82 | ACMSD (0.57) | ALDH1A1KMT2AHPGDMEN1SMN1; SMN2 | |
| SCHEMBL24088075 | 0.81 | LMNA (0.51) | KDM4EALDH1A1KMT2AHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12378200-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ORSOBIO, INC. (US) | 2025-08-05 | — | — | US | disclosed |
| US-20250145572-A1 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Inhibitors | ORSOBIO INC (US) | 2025-05-08 | — | — | US | disclosed |
| US-20240059657-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | OrsoBio Inc. | 2024-02-22 | — | — | US | disclosed |
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ORSOBIO, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ORSOBIO, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ORSOBIO, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20210094916-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | ORSOBIO, INC. | 2021-04-01 | — | — | US | disclosed |
| US-20210094916-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | ORSOBIO, INC. | 2021-04-01 | — | — | US | disclosed |
| WO-2018125983-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | MITOBRIDGE, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
| WO-2018125983-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | MITOBRIDGE, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12378200-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ALDH7A1, ACMSD, AMD1 | KDM4E 1040/4885ALDH1A1 370/4885KMT2A 1309/4885 |
| US-20250145572-A1 | Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Inhibitors | ACMSD, ALDH7A1, ALAD | KDM4E 807/4885ALDH1A1 271/4885KMT2A 978/4885 |
| US-20240059657-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | ALDH7A1, ACMSD, AMD1 | KDM4E 1040/4885ALDH1A1 370/4885KMT2A 1309/4885 |
| US-20210094916-A1 | OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS | ALDH7A1, OTC, DDC | KDM4E 1198/4885ALDH1A1 417/4885KMT2A 1374/4885 |
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ALDH7A1, ACMSD, AMD1 | KDM4E 1040/4885ALDH1A1 370/4885KMT2A 1309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.