Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.57 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.53 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1568575 | 0.86 | IMPDH2 (0.68) | ROCK2IMPDH2ROCK1NOTUMPRMT3 | |
| SCHEMBL20353458 | 0.85 | NOTUM (0.71) | ROCK2IMPDH2ROCK1NOTUMPRMT3 | |
| SCHEMBL29738320 | 0.82 | TAAR1 (0.64) | NOTUMTAAR1 | |
| SCHEMBL1568741 | 0.82 | IMPDH2 (0.63) | ROCK2IMPDH2ROCK1NOTUMPRMT3 | |
| SCHEMBL14124392 | 0.79 | ROCK2 (0.61) | ROCK2IMPDH2NOTUMPRMT3 | |
| SCHEMBL6630095 | 0.78 | IMPDH2 (0.64) | ROCK2IMPDH2ROCK1PRMT3 | |
| SCHEMBL3593323 | 0.76 | ROCK2 (0.58) | ROCK2IMPDH2ROCK1NOTUMPRMT3 | |
| SCHEMBL28574331 | 0.76 | KMT2A (0.68) | — | |
| SCHEMBL30209208 | 0.75 | IMPDH2 (0.54) | ROCK2IMPDH2ROCK1NOTUMPRMT3 | |
| SCHEMBL30209215 | 0.75 | IMPDH2 (0.54) | ROCK2IMPDH2ROCK1NOTUMPRMT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | ALCON INC. (CH) | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | COQ8A, PGC, AGK | ROCK2 246/4885IMPDH2 2131/4885ROCK1 375/4885 |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | COQ8A, PGC, AGK | ROCK2 246/4885IMPDH2 2131/4885ROCK1 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.