Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.61 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PRMT3 | O60678 | 3/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1568575 | 0.86 | IMPDH2 (0.68) | ROCK2IMPDH2ALDH1A1PRMT3NOTUM | |
| SCHEMBL1568741 | 0.83 | IMPDH2 (0.63) | ROCK2IMPDH2ALDH1A1SMN1; SMN2PRMT3 | |
| SCHEMBL19860093 | 0.81 | ROCK2 (0.61) | ROCK2IMPDH2ALDH1A1SMN1; SMN2PRMT3 | |
| SCHEMBL3593343 | 0.81 | ACHE (0.61) | ROCK2IMPDH2PRMT3NOTUM | |
| SCHEMBL20353459 | 0.79 | ROCK2 (0.57) | ROCK2IMPDH2PRMT3NOTUM | |
| SCHEMBL20353458 | 0.79 | NOTUM (0.71) | ROCK2IMPDH2PRMT3NOTUM | |
| SCHEMBL6630095 | 0.78 | IMPDH2 (0.64) | ROCK2IMPDH2ALDH1A1GAAHTT | |
| SCHEMBL3066012 | 0.78 | IMPDH2 (0.63) | ROCK2IMPDH2PRMT3NOTUM | |
| SCHEMBL19860042 | 0.77 | MEN1 (0.60) | ROCK2IMPDH2ALDH1A1PRMT3NOTUM | |
| SCHEMBL31514965 | 0.77 | IMPDH2 (0.68) | ROCK2IMPDH2PRMT3NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472327-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | ALCON INC. (CH) | 2018-07-05 | — | — | US | disclosed |
| WO-2008086269-A2 | 6-AMINOISOQUINOLINE COMPOUNDS USEFUL AS KINASE MODULATORS | AERIE PHARMACEUTICALS, INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| US-20080167340-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | US | disclosed |
| US-20080167340-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167340-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | ROCK2 246/4885IMPDH2 2131/4885ALDH1A1 2478/4885 |
| US-10472327-B2 | 6-aminoisoquinoline compounds | COQ8A, PGC, AGK | ROCK2 246/4885IMPDH2 2131/4885ALDH1A1 2478/4885 |
| US-20180186746-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | COQ8A, PGC, AGK | ROCK2 246/4885IMPDH2 2131/4885ALDH1A1 2478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.